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Maternal immunization : collaborating with Mother Nature Marchant, Arnaud; Sadarangani, Manish; Garand, Mathieu; Dauby, Nicolas; Verhasselt, Valerie; Pereira, Lenore; Bjornson, Gordean; Jones, Christine E.; Halperin, Scott A.; Edwards, Kathryn M.; et al.

Abstract

Maternal immunization offers much hope to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza and pertussis immunization during pregnancy has led to consideration of additional maternal immunization strategies to prevent Group B Streptococcus (GBS) and respiratory syncytial virus (RSV) infections, among others. However, there remain multiple gaps in our knowledge regarding the immunobiology of maternal immunization that prevent optimal design and application of this successful public health intervention. An innovative landscape analysis was therefore undertaken to identify research priorities. Key topics were delineated through review of the published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop gathering experts across several current maternal immunization initiatives - GBS, RSV, pertussis, and influenza. Finally, a global online survey prioritized the identified knowledge gaps based on expert opinion regarding their importance and relevance. This article presents the results of this worldwide landscape analysis and discusses the identified research gaps.

Item Metadata

Title
Maternal immunization : collaborating with Mother Nature
Creator
Marchant, Arnaud; Sadarangani, Manish; Garand, Mathieu; Dauby, Nicolas; Verhasselt, Valerie; Pereira, Lenore; Bjornson, Gordean; Jones, Christine E.; Halperin, Scott A.; Edwards, Kathryn M.; Heath, Paul; Openshaw, Peter J.; Scheifele, David W.; Kollmann, Tobias
Contributor
Children's Hospital (Vancouver, B.C.). Vaccine Evaluation Center
Date Issued
2017-07
Description
Maternal immunization offers much hope to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza and pertussis immunization during pregnancy has led to consideration of additional maternal immunization strategies to prevent Group B Streptococcus (GBS) and respiratory syncytial virus (RSV) infections, among others. However, there remain multiple gaps in our knowledge regarding the immunobiology of maternal immunization that prevent optimal design and application of this successful public health intervention. An innovative landscape analysis was therefore undertaken to identify research priorities. Key topics were delineated through review of the published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop gathering experts across several current maternal immunization initiatives - GBS, RSV, pertussis, and influenza. Finally, a global online survey prioritized the identified knowledge gaps based on expert opinion regarding their importance and relevance. This article presents the results of this worldwide landscape analysis and discusses the identified research gaps.
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2018-04-09
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0365268
URI
http://hdl.handle.net/2429/65243
Affiliation
Medicine, Faculty of; Non UBC; Infectious Diseases, Division of; Medicine, Department of; Pediatrics, Department of
Citation
Marchant, A., Sadarangani, M., Garand, M., Dauby, N., Verhasselt, V., Pereira, L.,...Kollmann, Tobias R. (2017). Maternal immunisation: Collaborating with mother nature. The Lancet Infectious Diseases, 17(7), E197-E208.
Publisher DOI
10.1016/S1473-3099(17)30229-3
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International