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Correction to: FLAGS, frequently mutated genes in public exomes Shyr, Casper; Tarailo-Graovac, Maja; Gottlieb, Michael; Lee, Jessica J; van Karnebeek, Clara; Wasserman, Wyeth W Nov 29, 2017

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CORRECTIONCorrection to: FLAGS, freqiebHGMD and FLAGS. (ZIP 677 bytes)MeSH terms, # of HPO terms, and # of paralogs). Table S9B. The list ofnumber of pathogenic variants from HGMD for each gene. (ZIP 900 kb)Institute, Vancouver, BC, Canada. Department of Medical Genetics, Universityof British Columbia, Vancouver, BC, Canada. 3Treatable Intellectual Disability4, University of7Shyr et al. BMC Medical Genomics  (2017) 10:69 DOI 10.1186/s12920-017-0309-71. Shyr et al., FLAGS, frequently mutated genes in public exomes. BMC MedGenomics 2014;7:64. DOI:10.1186/s12920-014-0064-y.2Department of Medical Genetics, University of British Columbia, Vancouver,BC, CanadaReference†Equal contributors1Centre for Molecular Medicine and Therapeutics, Child and Family ResearchInstitute, Vancouver, BC, CanadaAdditional file 8: Text S4. This section provides a description of theTIDE-BC project. (PDF 49 kb)Hospital, Vancouver, BC, Canada. Department of PediatricsBritish Columbia, Vancouver, BC, Canada.Received: 25 October 2017 Accepted: 21 November 201* Correspondence: wyeth@cmmt.ubc.caAdditional file 7: Text S3. This section contains a concise descriptionof our in-house bioinformatics pipeline for processing exome and wholegenome datasets. (PDF 48 kb)Endeavour in British Columbia, Vancouver, Canada. Bioinformatics GraduateProgram, University of British Columbia, Vancouver, BC, Canada. 5GenomeScience and Technology Graduate Program, University of British Columbia,Vancouver, BC, Canada. 6Division of Biochemical Diseases, BC Children’s72Additional file 5: Table S5. A table showing a comparison of dN/dSratio between the values we reported with our calculation (see manuscriptfor methodology), versus a previously published result of a gene set (referto reference [31] in the manuscript). The results between the twomethodologies were highly consistent. (TXT 692 bytes)Additional file 6: Table S9A. The list of input attributes for each genethat were fed into R for statistical analyses (dN/dS ratio, gene length, # ofgenes in public exomesCasper Shyr1,3,4†, Maja Tarailo-Graovac1,2,3†, Michael Gottland Wyeth W Wasserman1,2,3*CorrectionUnfortunately, the original article [1] contained an error.The additional files were included incorrectly. The cor-rect additional files 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13and 14 are published in this correction.Additional filesAdditional file 1: Table S1. This table lists the five datasets used in thisstudy, and the genes that made up each dataset. The first row in thetable shows the names of the datasets referred throughout the manuscript,and each column contains the list of genes, referred to by their official genesymbol (TXT 220 kb)Additional file 2: Table S6. A list of variants, in variant call format(VCF), showing the mutations that were observed more than 10 times inour in-house database consisting of 150 exomes and 13 whole genomes,after they were filtered by allelic frequencies according to the annotationsfrom dbSNP and Exome variant server (refer to methodology section formore details). (VCF 207 kb)Additional file 3: Table S4. The entire ranked list of FLAGS, with themost frequently mutated genes at the top. (TXT 185 kb)Additional file 4: Table S2A. The list of genes that overlap betweenOMIM and FLAGS. Table S2B. The list of genes that overlap between© The Author(s). 2017 Open Access This articInternational License (http://creativecommonsreproduction in any medium, provided you gthe Creative Commons license, and indicate if(http://creativecommons.org/publicdomain/zeOpen Accessuently mutated1, Jessica JY Lee1,5, Clara van Karnebeek3,6,7Additional file 9: Table S7. A summary of the families studied in TIDEXproject, and the number of candidate variants remaining after filteringagainst genetic and allelic frequency thresholds. The results are brokendown by family structure and the types of genetic model applied. Referto www.tidebc.org and additional text S4 for more information on theTIDEX project, and additional text S3 for how the variants were calledand filtered. (TXT 2 kb)Additional file 10: Table S8. A table of number of exomes from TIDEXproject that lists out the number of rare functional variants for eachprotein-coding gene captured in the exome capture kits. Please refer tomethodology section for how ‘rare’ and ‘functional’ descriptors weredefined. (TXT 81 kb)Additional file 11: Text S2. A comparison of our FLAGS gene rankingsystem against another method, residual variation intolerance score (RVIS)that also built upon public genomic datasets and ranked importance ofeach gene’s association to human diseases. Agreements and disagreementsbetween the two methods are discussed. (PDF 48 kb)Additional file 12: Text S5. This section describes an analysis lookingat the distribution of number of MeSH and HPO terms per gene, afternormalizing by the number of biological functionally-related literaturepublished for that gene, as reported in GeneRIF. (PDF 46 kb)Additional file 13: Text S1. This section describes an analysis lookingat the uniformity of distribution for rare functional variants across genes.The hypothesis was that genes of less significance to monogenic humandiseases would display more uniformity in the occurrences of benigncoding mutations across the protein sequence, whereas genes that aremore linked to causing penetrating diseases would harbor regions thatare more devoid of mutations due to conservation of important proteindomains. (PDF 47 kb)Additional file 14: The PDF outlining the supplementary informationfor this manuscript. (PDF 108 kb)Author details1Centre for Molecular Medicine and Therapeutics, Child and Family Researchle is distributed under the terms of the Creative Commons Attribution 4.0.org/licenses/by/4.0/), which permits unrestricted use, distribution, andive appropriate credit to the original author(s) and the source, provide a link tochanges were made. The Creative Commons Public Domain Dedication waiverro/1.0/) applies to the data made available in this article, unless otherwise stated.


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