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HIV Viral Suppression Results in Higher Antibody Responses in HIV-Positive Women Vaccinated with the Quadrivalent Human Papillomavirus Vaccine Money, Deborah M.; Moses, Erin; Blitz, Sandra; Vandriel, Shannon M.; Lipsky, Nancy; Walmsley, Sharon L.; Loutfy, Mona R.; Trottier, Sylvie; Smaill, Fiona; Yudin, Mark H.; Klein, Marina B.; Harris, Marianne; Cohen, Jeffrey; Wobeser, Wendy; Bitnun, Ari; Lapointe, Normand; Samson, Lindy; Brophy, Jason; Karatzios, Christos; Ogilvie, Gina; Coutlée, François; Raboud, Janet; HPV in HIV Study Group

Abstract

Objective: To evaluate the immunogenicity and safety of the quadrivalent HPV (qHPV) vaccine in HIV-positive women over 24 months. Design: Between November 2008 and December 2012, 372 women aged 15 and older were enrolled from 14 Canadian HIV outpatient clinics in an open label cohort study. The qHPV vaccine (0.5 mL) was administered intramuscularly at months 0, 2 and 6. The primary study endpoint was seroconversion to any of the HPV types targeted by the qHPV vaccine. Antibody levels were measured at 0, 2, 7, 18, and 24 months. Adverse events were recorded throughout. Results: Of 372 participants enrolled, 310 (83%) received at least one dose of the qHPV vaccine and 277 (74%) received all three doses. Ninety-five percent (293/308) were seronegative for at least one vaccine type at baseline. The median age was 38 years (IQR 32-45, range 15-66), 36% were white, 44% black and 13% were of Indigenous origin. Seventy-two percent of participants had suppressed HIV viral load (VL

Item Metadata

Title
HIV Viral Suppression Results in Higher Antibody Responses in HIV-Positive Women Vaccinated with the Quadrivalent Human Papillomavirus Vaccine
Creator
Money, Deborah M.; Moses, Erin; Blitz, Sandra; Vandriel, Shannon M.; Lipsky, Nancy; Walmsley, Sharon L.; Loutfy, Mona R.; Trottier, Sylvie; Smaill, Fiona; Yudin, Mark H.; Klein, Marina B.; Harris, Marianne; Cohen, Jeffrey; Wobeser, Wendy; Bitnun, Ari; Lapointe, Normand; Samson, Lindy; Brophy, Jason; Karatzios, Christos; Ogilvie, Gina; Coutlée, François; Raboud, Janet; HPV in HIV Study Group
Date Issued
2016-09
Description
Objective: To evaluate the immunogenicity and safety of the quadrivalent HPV (qHPV) vaccine in HIV-positive women over 24 months. Design: Between November 2008 and December 2012, 372 women aged 15 and older were enrolled from 14 Canadian HIV outpatient clinics in an open label cohort study. The qHPV vaccine (0.5 mL) was administered intramuscularly at months 0, 2 and 6. The primary study endpoint was seroconversion to any of the HPV types targeted by the qHPV vaccine. Antibody levels were measured at 0, 2, 7, 18, and 24 months. Adverse events were recorded throughout. Results: Of 372 participants enrolled, 310 (83%) received at least one dose of the qHPV vaccine and 277 (74%) received all three doses. Ninety-five percent (293/308) were seronegative for at least one vaccine type at baseline. The median age was 38 years (IQR 32-45, range 15-66), 36% were white, 44% black and 13% were of Indigenous origin. Seventy-two percent of participants had suppressed HIV viral load (VL
Subject
HIV-positive; Human Papillomavirus Vaccines; Immunogenicity; Safety; HPV Antibody Response
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2017-08-17
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0354417
URI
http://hdl.handle.net/2429/62678
Affiliation
Medicine, Faculty of; Non UBC; Family Practice, Department of; Obstetrics and Gynaecology, Department of; Pathology and Laboratory Medicine, Department of; Pediatrics, Department of; Population and Public Health (SPPH), School of; Medicine, Department of
Citation
Money D, Moses E, Blitz S, Vandriel SM, Lipsky N, Walmsley SL, Loutfy M, Trottier S, Smaill F, Yudin M, Klein M, Harris M, Cohen J, Wobeser W, Bitnun A, Lapointe N, Samson L, Brophy J, Karatzios C, Ogilvie G, Coutlée F, Raboud J, & the HPV in HIV Study Group. HIV viral suppression results in higher antibody responses in HIV-positive women vaccinated with the quadrivalent human papillomavirus vaccine. Vaccine. 2016 Sep,34(4). 4799-4806. PMID: 27544584
Peer Review Status
Reviewed
Scholarly Level
Faculty; Unknown
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Attribution-NonCommercial-NoDerivatives 4.0 International