UBC Faculty Research and Publications

HIV Viral Suppression Results in Higher Antibody Responses in HIV-Positive Women Vaccinated with the… Money, Deborah M.; Moses, Erin; Blitz, Sandra; Vandriel, Shannon M.; Lipsky, Nancy; Walmsley, Sharon L.; Loutfy, Mona R.; Trottier, Sylvie; Smaill, Fiona; Yudin, Mark H.; Klein, Marina; Harris, Marianne; Cohen, Jeffrey; Wobeser, Wendy; Bitnun, Ari; Lapointe, Normand; Samson, Lindy; Brophy, Jason; Karatzios, Christos; Ogilvie, Gina; Coutlée, François; Raboud, Janet; HPV in HIV Study Group Sep 30, 2016

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Table 4: Antibody response in per-protocol efficacy HIV-positive women compared to HIV-417 negative women ages 15-26 & 24-45 418 419 HIV-negative women HIV-positive women Age Group Month HPV Type N GMT (95%CI) N GMT (95%CI) p value 15-26 years† 7 6 2635 543 (526, 560) 16 708 (422,1190) 0.29 11 2659 762 (735, 789) 21 595 (397,892) 0.22 16 2573 2294 (2185, 2408) 18 3473 (2168,5566) 0.08 18 2800 462 (444, 480) 19 334 (189,591) 0.25 24 6 2438 113 (109,118) 10 118 (52,267) 0.91 11 2469 145 (139, 150) 13 81  (38,172) 0.12 16 2381 460 (441, 481) 12 319 (167,610) 0.24 18 2603 52 (49, 55) 14 16  (9,27) <0.001 24-45 years‡ 7 6 1249 416 61 426 (324,561) 0.86 11 1249 551 98 540 (436,668) 0.85 16 1269 2226 66 1495 (1046,2137) 0.03 18 1430 357 94 295.0 (223,391) 0.18 24 6 1207 70 53 129 (93,179) <0.001 11 1207 78 78 125 (97,160) <0.001 16 1225 279 54 459 (341,618) <0.01 18 1378 28 72 54  (39,74) <0.0001 † Joura Vaccine 2008 420 ‡ Castellsague Br J Cancer 2011 421 GMT = geometric mean titre; CI = confidence interval 422 

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