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Abstract

To examine the mechanism of weight loss following ileogastrostomy, 16 morbidly obese subjects (36±2 years, 45.6±1.1 kg.m ²⁻¹ body mass index (BMI), 48.2±1.0% body fat(BF) (mean±SEM)) were selected and tested prior to and after this procedure. Due to various reasons, complete data were not obtained from any one subject although a total of 16 bypass patients participated in the study. Therefore, the number of subjects in each part of the study varied from six to ten. Body composition was determined using the isotope dilution space (IDS) method and bioelectrical impedanceanalysis (BIA), which were compared with dual energy x-ray absorptiometry (DEXA) measurements in a subgroup of the participants. Gas exchange analysis was used to measure the changes in basal energy expenditure (BEE) and thermic effect of food (TEF). Total energy expenditure (TEE) was determined during 6-8 weeks after surgery using the doubly labeled water (DLW) method. Weighed food records were used to assess the changes in energy intake during the study period. A group of normal-weight women (48±1 years, 23.4±0.5 kg.m ²⁻¹ BMI, 32.8±1.3 %BF (mean±SEM)) was selected to supplement the overall research. Average body weight (111.1±3.2 kg, n=7) of the subjects completing the 3-month measurement decreased by 5.2, 4.2 and 7.8 kg during each of the three months. There was a significant decline (p