Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability

UBC Undergraduate Research

Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability Moosvi, Firas

Abstract

Galbumin, an MR contrast agent is characterized for use in a new class of animal MR experiments. It’s suitability as both a T1 and T2 agent was assessed and it was found that although Galbumin’s relaxivity (4.33 to 5.77 (mM · sec)−1 was comparable to Gd-DTPA, the solution was not available at a high enough concentration to achieve similar T1 weighted effects. Further, it was deemed an unworthy candidate for T2 -weighted imaging as it’s magnetic susceptibility was much too low (2.95 ppm/mM). Finally, we established a theoretical basis for a novel dual contrast agent MR protocol to investigate blood vessel permeability, extracted from previously published work [1] on modelling MR contrast agents. The over-arching goal of this study is to use the live imaging capabilities of MR combined with traditional immunohistochemical techniques to more accurately characterize tumour vessel permeability.

Item Metadata

Title	Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability
Creator	Moosvi, Firas
Date Issued	2009-05-01
Description	Galbumin, an MR contrast agent is characterized for use in a new class of animal MR experiments. It’s suitability as both a T1 and T2 agent was assessed and it was found that although Galbumin’s relaxivity (4.33 to 5.77 (mM · sec)−1 was comparable to Gd-DTPA, the solution was not available at a high enough concentration to achieve similar T1 weighted effects. Further, it was deemed an unworthy candidate for T2 -weighted imaging as it’s magnetic susceptibility was much too low (2.95 ppm/mM). Finally, we established a theoretical basis for a novel dual contrast agent MR protocol to investigate blood vessel permeability, extracted from previously published work [1] on modelling MR contrast agents. The over-arching goal of this study is to use the live imaging capabilities of MR combined with traditional immunohistochemical techniques to more accurately characterize tumour vessel permeability.
Extent	7225461 bytes
Genre	Graduating Project
Type	Text
File Format	application/pdf
Language	eng
Series	University of British Columbia. PHYS 449
Date Available	2009-05-01
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0085960
URI	http://hdl.handle.net/2429/7804
Affiliation	Science, Faculty of; Physics and Astronomy, Department of
Campus	UBCV
Citation	Moosvi, Firas. 2009. Characterizing Tumour Vessels using MRI and Histology - A novel dual injection MR protocol to study tumour blood vessel permeability. Undergraduate Honours Thesis. Department of Physics and Astronomy. University of British Columbia.
Peer Review Status	Unreviewed
Scholarly Level	Undergraduate
Copyright Holder	Moosvi, Firas
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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