Open Collections

UBC Faculty Research and Publications

Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts Alhussan, Abdulaziz; Jackson, Nolan; Dos Santos, Nancy; Chen, Sam; Tam, Yuen Yi C.; Chithrani, Devika B.

Abstract

Cancer treatments are limited by poor tumor specificity and toxicity. We tested a radiosensitizing approach using PEG/RGD-functionalized gold nanoparticles (GNPs), a lipid-nanoparticle–encapsulated docetaxel prodrug (LNPDTX–P), and external-beam radiotherapy (RT). In MIA PaCa-2 xenografts, intravenous GNPs (2 mg/kg) and LNPDTX–P (6 mg/kg) were given before 5 Gy RT. Both LNPDTX–P + RT and GNPs + LNPDTX–P + RT reduced tumor volume by ~40% and significantly prolonged survival versus RT alone (p < 0.001). Adding GNPs did not enhance efficacy, indicating LNPDTX–P was the main driver under this regimen. These results demonstrate nanocarrier-enabled radiosensitization in vivo and support further studies toward clinical translation.

Item Metadata

Title
Radiosensitization by Docetaxel Prodrug-Loaded Lipid Nanoparticles in Pancreatic Cancer Xenografts
Creator
Alhussan, Abdulaziz; Jackson, Nolan; Dos Santos, Nancy; Chen, Sam; Tam, Yuen Yi C.; Chithrani, Devika B.
Contributor
BC Cancer Research Centre. Department of Experimental Therapeutics
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2025-10-05
Description
Cancer treatments are limited by poor tumor specificity and toxicity. We tested a radiosensitizing approach using PEG/RGD-functionalized gold nanoparticles (GNPs), a lipid-nanoparticle–encapsulated docetaxel prodrug (LNPDTX–P), and external-beam radiotherapy (RT). In MIA PaCa-2 xenografts, intravenous GNPs (2 mg/kg) and LNPDTX–P (6 mg/kg) were given before 5 Gy RT. Both LNPDTX–P + RT and GNPs + LNPDTX–P + RT reduced tumor volume by ~40% and significantly prolonged survival versus RT alone (p < 0.001). Adding GNPs did not enhance efficacy, indicating LNPDTX–P was the main driver under this regimen. These results demonstrate nanocarrier-enabled radiosensitization in vivo and support further studies toward clinical translation.
Subject
docetaxel; lipid nanoparticles; radiotherapy; cancer; docetaxel prodrug; radiosensitization; nanotechnology; combined modality therapy; gold nanoparticles
Genre
Article
Type
Text
Language
eng
Date Available
2025-10-27
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0450555
URI
http://hdl.handle.net/2429/92727
Affiliation
Medicine, Faculty of; Science, Irving K. Barber Faculty of (Okanagan); Non UBC; Biochemistry and Molecular Biology, Department of; Computer Science, Mathematics, Physics and Statistics, Department of (Okanagan)
Citation
Nanomaterials 15 (19): 1521 (2025)
Publisher DOI
10.3390/nano15191521
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

Item Media

Item Citations and Data

Rights

CC BY 4.0