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Abstract

Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease often affecting infants. However, its significance in adult populations is increasingly recognized. Notably, its prevalence and impact among elderly individuals remain poorly understood, highlighting the need for a deeper understanding of its global burden. This study aims to evaluate the prevalence, incidence, and Disability-Adjusted Life Years (DALYs) of AD in individuals aged 60 and older from 1990 to 2021, with projections to 2045. Methods: Data from the Global Burden of Disease (GBD) Study were used to analyze trends in the global burden of AD by region and sex. Key metrics were calculated using annual average percentage changes (AAPC). Based on historical trends, projections for 2022–2045 were developed. Results: In 2021, the prevalence of AD in the elderly exhibited substantial regional variation, with the highest rates observed in Northern Europe and North America. Although global prevalence slightly declined from 1990 to 2021, females consistently demonstrated a higher burden than males. Projections indicate a substantial increase in AD cases by 2045, particularly among elderly females, with the 60–64 age group expected to exceed 4 million cases. The disease burden correlated with Universal Health Coverage (UHC) indices, suggesting healthcare access impacts disease reporting and management. Conclusions: The increasing burden of AD, especially in elderly females, highlights the urgent need for targeted healthcare strategies to manage AD in aging populations. Further research is required to address regional and gender disparities in AD care.