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Antibodies Against SARS-CoV-2 Do Not Cross-React with Endemic Coronaviruses in a Pediatric Population: Data from a Bangladesh Cohort Márquez, Ana Citlali; Tanunliong, Guadalein; Kabir, Mamun; Alam, Masud; Hossain, Biplob; Rashid, Humaira; Jassem, Agatha; Sekirov, Inna; Haque, Rashidul; Morshed, Muhammad

Abstract

There is a limited understanding of the immunological differences between children and adults that protect children from developing severe coronavirus disease 2019 (COVID-19) following SARS-CoV-2 infection. Previous infection with endemic human coronaviruses (HCoVs) has been suggested as a factor. In this study, we used 100 paired residual samples collected before and during the COVID-19 pandemic from children in Bangladesh. We compared the changes in their sero-status (no COVID-19 vs. COVID-19) and quantified antibody levels to HCoVs. We found that although 45% of the children seroconverted for IgG antibodies against SARS-CoV-2, there was no correlation between evidence of previous infection with HCoVs and the magnitude of SARS-CoV-2 antibody responses post-infection. Moreover, no differences in the anti-HCoV antibody levels were found pre- and post-SARS-CoV-2 infection.

Item Metadata

Title
Antibodies Against SARS-CoV-2 Do Not Cross-React with Endemic Coronaviruses in a Pediatric Population: Data from a Bangladesh Cohort
Creator
Márquez, Ana Citlali; Tanunliong, Guadalein; Kabir, Mamun; Alam, Masud; Hossain, Biplob; Rashid, Humaira; Jassem, Agatha; Sekirov, Inna; Haque, Rashidul; Morshed, Muhammad
Contributor
BC Centre for Disease Control
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2025-01-24
Description
There is a limited understanding of the immunological differences between children and adults that protect children from developing severe coronavirus disease 2019 (COVID-19) following SARS-CoV-2 infection. Previous infection with endemic human coronaviruses (HCoVs) has been suggested as a factor. In this study, we used 100 paired residual samples collected before and during the COVID-19 pandemic from children in Bangladesh. We compared the changes in their sero-status (no COVID-19 vs. COVID-19) and quantified antibody levels to HCoVs. We found that although 45% of the children seroconverted for IgG antibodies against SARS-CoV-2, there was no correlation between evidence of previous infection with HCoVs and the magnitude of SARS-CoV-2 antibody responses post-infection. Moreover, no differences in the anti-HCoV antibody levels were found pre- and post-SARS-CoV-2 infection.
Subject
SARS-CoV-2; COVID-19; HCoVs
Genre
Article
Type
Text
Language
eng
Date Available
2025-02-28
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0448146
URI
http://hdl.handle.net/2429/90440
Affiliation
Medicine, Faculty of; Non UBC; Pathology and Laboratory Medicine, Department of
Citation
Viruses 17 (2): 161 (2025)
Publisher DOI
10.3390/v17020161
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0