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Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections Wasan, Ellen; Mandava, Tavonga; Crespo-Moran, Pablo; Nagy, Adrienne; Wasan, Kishor M.

Abstract

Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-borne parasitic and fungal infections. However, its use, particularly in the developing world, has been limited by dose-dependent kidney toxicity, other systemic-related toxicity issues following injection, the inconvenience of parenteral administration, and accessibility. Oral formulation approaches have focused on the dual problem of solubility and permeability of AmpB, which is poorly water soluble, amphoteric and has extremely low oral bioavailability. Therefore, to enhance oral absorption, researchers have employed micellar formulations, polymeric nanoparticles, cochleates, pro-drugs, and self-emulsifying drug delivery systems (SEDDS). This paper will highlight current uses of AmpB against parasitic infections such as leishmaniasis, preclinical and clinical formulation strategies, applications in veterinary medicine and the importance of developing a cost-effective and safe oral AmpB formulation.

Item Metadata

Title
Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections
Creator
Wasan, Ellen; Mandava, Tavonga; Crespo-Moran, Pablo; Nagy, Adrienne; Wasan, Kishor M.
Contributor
University of British Columbia. Neglected Global Diseases Initiative
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-10-28
Description
Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-borne parasitic and fungal infections. However, its use, particularly in the developing world, has been limited by dose-dependent kidney toxicity, other systemic-related toxicity issues following injection, the inconvenience of parenteral administration, and accessibility. Oral formulation approaches have focused on the dual problem of solubility and permeability of AmpB, which is poorly water soluble, amphoteric and has extremely low oral bioavailability. Therefore, to enhance oral absorption, researchers have employed micellar formulations, polymeric nanoparticles, cochleates, pro-drugs, and self-emulsifying drug delivery systems (SEDDS). This paper will highlight current uses of AmpB against parasitic infections such as leishmaniasis, preclinical and clinical formulation strategies, applications in veterinary medicine and the importance of developing a cost-effective and safe oral AmpB formulation.
Subject
oral amphotericin B; safety and tolerability; pharmacokinetics; parasitic infections; human use; veterinary use; nanomedicines; drug delivery; nanoparticles; SEDDS
Genre
Article
Type
Text
Language
eng
Date Available
2025-01-27
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0447851
URI
http://hdl.handle.net/2429/90213
Affiliation
Medicine, Faculty of; Non UBC; Urologic Sciences, Department of
Citation
Pharmaceutics 14 (11): 2316 (2022)
Publisher DOI
10.3390/pharmaceutics14112316
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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CC BY 4.0