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Lin28 Regulates Cancer Cell Stemness for Tumour Progression Lin, Zhuohui; Radaeva, Mariia; Cherkasov, Artem; Dong, Xuesen

Abstract

Tumours develop therapy resistance through complex mechanisms, one of which is that cancer stem cell (CSC) populations within the tumours present self-renewable capability and phenotypical plasticity to endure therapy-induced stress conditions and allow tumour progression to the therapy-resistant state. Developing therapeutic strategies to cope with CSCs requires a thorough understanding of the critical drivers and molecular mechanisms underlying the aforementioned processes. One such hub regulator of stemness is Lin28, an RNA-binding protein. Lin28 blocks the synthesis of let-7, a tumour-suppressor microRNA, and acts as a global regulator of cell differentiation and proliferation. Lin28also targets messenger RNAs and regulates protein translation. In this review, we explain the role of the Lin28/let-7 axis in establishing stemness, epithelial-to-mesenchymal transition, and glucose metabolism reprogramming. We also highlight the role of Lin28 in therapy-resistant prostate cancer progression and discuss the emergence of Lin28-targeted therapeutics and screening methods.

Item Metadata

Title
Lin28 Regulates Cancer Cell Stemness for Tumour Progression
Creator
Lin, Zhuohui; Radaeva, Mariia; Cherkasov, Artem; Dong, Xuesen
Contributor
Vancouver Prostate Centre
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-09-24
Description
Tumours develop therapy resistance through complex mechanisms, one of which is that cancer stem cell (CSC) populations within the tumours present self-renewable capability and phenotypical plasticity to endure therapy-induced stress conditions and allow tumour progression to the therapy-resistant state. Developing therapeutic strategies to cope with CSCs requires a thorough understanding of the critical drivers and molecular mechanisms underlying the aforementioned processes. One such hub regulator of stemness is Lin28, an RNA-binding protein. Lin28 blocks the synthesis of let-7, a tumour-suppressor microRNA, and acts as a global regulator of cell differentiation and proliferation. Lin28also targets messenger RNAs and regulates protein translation. In this review, we explain the role of the Lin28/let-7 axis in establishing stemness, epithelial-to-mesenchymal transition, and glucose metabolism reprogramming. We also highlight the role of Lin28 in therapy-resistant prostate cancer progression and discuss the emergence of Lin28-targeted therapeutics and screening methods.
Subject
Lin28; let-7; metastasis; metabolism; epithelial-to-mesenchymal transition; prostate cancer; cancer stem cell; Lin28 inhibitors
Genre
Article
Type
Text
Language
eng
Date Available
2024-11-01
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0447193
URI
http://hdl.handle.net/2429/89590
Affiliation
Land and Food Systems, Faculty of; Medicine, Faculty of; Science, Faculty of; Non UBC; Microbiology and Immunology, Department of; Urologic Sciences, Department of
Citation
Cancers 14 (19): 4640 (2022)
Publisher DOI
10.3390/cancers14194640
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0