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Costiniuk, Cecilia T.; Lee, Terry C. K.; Singer, Joel; Galipeau, Yannick; Arnold, Corey; Langlois, Marc-André; Needham, Judy; Jenabian, Mohammad-Ali; Burchell, Ann N.; Samji, Hasina; Chambers, Catharine; Walmsley, Sharon; Ostrowski, Mario; Kovacs, Colin; Tan, Darrell H. S.; Harris, Marianne; Hull, Mark W.; Brumme, Zabrina L.; Lapointe, Hope R.; Brockman, Mark A.; Margolese, Shari; Mandarino, Enrico; Samarani, Suzanne; Lebouché, Bertrand; Angel, Jonathan B.; Routy, Jean-Pierre; Cooper, Curtis L.; Anis, Aslam H. (Aslam Hayat), 1959-

Multidisciplinary Digital Publishing Institute

COVID-19 breakthrough infection (BTI) can occur despite vaccination. Using a multi-centre, prospective, observational Canadian cohort of people with HIV (PWH) receiving ≥2 COVID-19 vaccines, we compared the SARS-CoV-2 spike (S) and receptor-binding domain (RBD)-specific IgG levels 3 and 6 months post second dose, as well as 1 month post third dose, in PWH with and without BTI. BTI was defined as positivity based on self-report measures (data up to last study visit) or IgG data (up to 1 month post dose 3). The self-report measures were based on their symptoms and either a positive PCR or rapid antigen test. The analysis was restricted to persons without previous COVID-19 infection. Persons without BTI remained COVID-19-naïve until ≥3 months following the third dose. Of 289 participants, 92 developed BTI (31.5 infections per 100 person-years). The median days between last vaccination and BTI was 128 (IQR 67, 176), with the most cases occurring between the third and fourth dose (n = 59), corresponding to the Omicron wave. In analyses adjusted for age, sex, race, multimorbidity, hypertension, chronic kidney disease, diabetes and obesity, a lower IgG S/RBD (log10 BAU/mL) at 1 month post dose 3 was significantly associated with BTI, suggesting that a lower IgG level at this time point may predict BTI in this cohort of PWH.

Article

eng

Vancouver : University of British Columbia Library

10.14288/1.0443769

Medicine, Faculty of; Non UBC; Population and Public Health (SPPH), School of

10.3390/vaccines12050447

Faculty; Researcher

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