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Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases Antony, Irene Rose; Wong, Brandon Han Siang; Kelleher, Dermot; Verma, Navin Kumar

Abstract

Immune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to affected tissue sites are crucial for mounting an adaptive immune response. An effective adaptive immune defense depends on the ability of T-cells to dynamically reprogram their metabolic requirements in response to environmental cues. Inability of the T-cells to adapt to specific metabolic demands may skew cells to become either hyporesponsive (creating immunocompromised conditions) or hyperactive (causing autoimmune tissue destruction). Here, we review maladaptive T-cell metabolic fitness that can cause autoimmune diseases and discuss how T-cell metabolic programs can potentially be modulated to achieve therapeutic benefits.

Item Metadata

Title
Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases
Creator
Antony, Irene Rose; Wong, Brandon Han Siang; Kelleher, Dermot; Verma, Navin Kumar
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-10-29
Description
Immune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to affected tissue sites are crucial for mounting an adaptive immune response. An effective adaptive immune defense depends on the ability of T-cells to dynamically reprogram their metabolic requirements in response to environmental cues. Inability of the T-cells to adapt to specific metabolic demands may skew cells to become either hyporesponsive (creating immunocompromised conditions) or hyperactive (causing autoimmune tissue destruction). Here, we review maladaptive T-cell metabolic fitness that can cause autoimmune diseases and discuss how T-cell metabolic programs can potentially be modulated to achieve therapeutic benefits.
Subject
autoimmunity; glycolysis; LFA-1; metabolites; psoriasis; rheumatoid arthritis; T-cell function; T-cell motility
Genre
Article
Type
Text
Language
eng
Date Available
2023-11-16
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437697
URI
http://hdl.handle.net/2429/86544
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
Cells 12 (21): 2541 (2023)
Publisher DOI
10.3390/cells12212541
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Postdoctoral
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0