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Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease Bogoslowski, Ania; An, Meilin; Penninger, Josef

Abstract

Organoid-based research has made significant discoveries and contributions to our understanding of human organ function in both health and disease. To continue making progress, it is crucial to acknowledge the crucial role of the immune system in all organs. Various immune cells, such as macrophages, T cells, and neutrophils, are resident in almost all human tissues and play essential roles in organ homeostasis, function, and disease. Using diverse methods, researchers have begun integrating immune cells into organoid models, leading to more physiologically relevant models that better represent various aspects of human disease. These methods range from immune cell injection to co-culture and tissue expansion with existing immune cells. Immune cells can be sourced from mature patients or generated from stem cells as immature immune cells. The successful incorporation of immune cells into organoids will enhance our understanding of organ function and provide a more accurate approximation of human disease.

Item Metadata

Title
Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease
Creator
Bogoslowski, Ania; An, Meilin; Penninger, Josef
Contributor
University of British Columbia. Life Sciences Institute
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-08-12
Description
Organoid-based research has made significant discoveries and contributions to our understanding of human organ function in both health and disease. To continue making progress, it is crucial to acknowledge the crucial role of the immune system in all organs. Various immune cells, such as macrophages, T cells, and neutrophils, are resident in almost all human tissues and play essential roles in organ homeostasis, function, and disease. Using diverse methods, researchers have begun integrating immune cells into organoid models, leading to more physiologically relevant models that better represent various aspects of human disease. These methods range from immune cell injection to co-culture and tissue expansion with existing immune cells. Immune cells can be sourced from mature patients or generated from stem cells as immature immune cells. The successful incorporation of immune cells into organoids will enhance our understanding of organ function and provide a more accurate approximation of human disease.
Subject
organoids; co-culture; immune cells; disease modelling; tumour organoids; stem cell research; resident immune cells
Genre
Article
Type
Text
Language
eng
Date Available
2023-10-27
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437387
URI
http://hdl.handle.net/2429/86365
Affiliation
Medicine, Faculty of; Non UBC; Medical Genetics, Department of
Citation
Organoids 2 (3): 140-155 (2023)
Publisher DOI
10.3390/organoids2030011
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0