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Targeting SARS-CoV-2 Non-Structural Proteins Tam, Donald; Lorenzo-Leal, Ana C.; Hernández, Luis Ricardo; Bach, Horacio

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.

Item Metadata

Title
Targeting SARS-CoV-2 Non-Structural Proteins
Creator
Tam, Donald; Lorenzo-Leal, Ana C.; Hernández, Luis Ricardo; Bach, Horacio
Contributor
University of British Columbia. Division of Infectious Diseases
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2023-08-20
Description
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.
Subject
SARS-CoV-2; non-structural protein; virulence factors; drug targeting; multi-drug regimen; replication transcription complex; RNA capping machinery
Genre
Article
Type
Text
Language
eng
Date Available
2023-10-27
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0437385
URI
http://hdl.handle.net/2429/86363
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
International Journal of Molecular Sciences 24 (16): 13002 (2023)
Publisher DOI
10.3390/ijms241613002
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0