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Finding the lowest effective dose for non-opioid analgesics Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 134 explores effective dosing for non-opioid analgesics. Conclusions: Most patients do not obtain clinically meaningful pain relief at any dose of cyclobenzaprine, duloxetine, gabapentin, or pregabalin. High doses are unlikely to improve analgesia more than lower doses. They do increase harms. Clinical impacts of dose changes (good or bad) should usually be apparent within 1 week. Spontaneous improvement can appear to be a beneficial drug effect, even when it would have occurred without drug therapy. Try short therapeutic trials and periodic reassessment of patients whose pain improves during drug therapy.

Item Metadata

Title
Finding the lowest effective dose for non-opioid analgesics
Alternate Title
Therapeutics Letter 134
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2021-12
Description
Therapeutics Letter 134 explores effective dosing for non-opioid analgesics. Conclusions: Most patients do not obtain clinically meaningful pain relief at any dose of cyclobenzaprine, duloxetine, gabapentin, or pregabalin. High doses are unlikely to improve analgesia more than lower doses. They do increase harms. Clinical impacts of dose changes (good or bad) should usually be apparent within 1 week. Spontaneous improvement can appear to be a beneficial drug effect, even when it would have occurred without drug therapy. Try short therapeutic trials and periodic reassessment of patients whose pain improves during drug therapy.
Subject
Analgesia; Analgesics, Non-Narcotic; Cyclobenzaprine; Duloxetine Hydrochloride; Gabapentin; Pain; Pregabalin
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433713
URI
http://hdl.handle.net/2429/85123
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International