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Serious harms with long-term PPI use in older adults Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 126 considers serious harms with long-term proton pump inhibitor use in older adults. Conclusions: Observational studies have identified signals of serious harms from long-term PPI exposure, including an increased risk of death. Even large RCTs may not detect these, if exposure or follow-up are insufficiently long. The COMPASS trial findings are not inconsistent with contemporaneous findings from observational studies. Clinicians and patients can reverse the relentless expansion of long-term PPI exposure by reviewing indications and considering potential harms as well as benefits.

Item Metadata

Title
Serious harms with long-term PPI use in older adults
Alternate Title
Therapeutics Letter 126
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2020-04
Description
Therapeutics Letter 126 considers serious harms with long-term proton pump inhibitor use in older adults. Conclusions: Observational studies have identified signals of serious harms from long-term PPI exposure, including an increased risk of death. Even large RCTs may not detect these, if exposure or follow-up are insufficiently long. The COMPASS trial findings are not inconsistent with contemporaneous findings from observational studies. Clinicians and patients can reverse the relentless expansion of long-term PPI exposure by reviewing indications and considering potential harms as well as benefits.
Subject
Drug-Related Side Effects and Adverse Reactions; Proton Pump Inhibitors
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433705
URI
http://hdl.handle.net/2429/85115
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International