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Do statins have a role in primary prevention? An update. Therapeutics Initiative (University of British Columbia)

Description

Therapeutics Letter 77 explores the role of statins in primary prevention using Cochrane Collaboration methodology. Conclusions: Systematic reviews and meta-analyses are challenging and require much more than locating RCTs and plugging in the numbers. The claimed mortality benefit of statins for primary prevention is more likely a measure of bias than a real effect. The reduction in major CHD serious adverse events with statins as compared to placebo is not reflected in a reduction in total serious adverse events. Statins do not have a proven net health benefit in primary prevention populations and thus when used in that setting do not represent good use of scarce health care resources.

Item Metadata

Title
Do statins have a role in primary prevention? An update.
Alternate Title
Therapeutics Letter 77
Creator
Therapeutics Initiative (University of British Columbia)
Date Issued
2010-04
Description
Therapeutics Letter 77 explores the role of statins in primary prevention using Cochrane Collaboration methodology. Conclusions: Systematic reviews and meta-analyses are challenging and require much more than locating RCTs and plugging in the numbers. The claimed mortality benefit of statins for primary prevention is more likely a measure of bias than a real effect. The reduction in major CHD serious adverse events with statins as compared to placebo is not reflected in a reduction in total serious adverse events. Statins do not have a proven net health benefit in primary prevention populations and thus when used in that setting do not represent good use of scarce health care resources.
Subject
Bias; Coronary Disease; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mortality; Primary Prevention
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433656
URI
http://hdl.handle.net/2429/85066
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International