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The serotonin transporter promoter variant, stress, and attentional biases in middle childhood Kotelnikova, Yuliya; LeMoult, Joelle; Mackrell, Sarah V. M.; Sheikh, Haroon I.; Singh, Shiva M.; Joormann, Jutta; Gotlib, Ian H.; Hayden, Elizabeth P.

Abstract

Although evidence suggests that 5-HTTLPR variants may shape risk for depression, the influence is likely complex, and involves effects on endophenotypes. We examined associations between 5-HTTLPR and biases in attention to affective stimuli in a sample of girls and a sample of both boys and girls. Children with at least one short (S) variant of the 5-HTTLPR polymorphism had lower positive attentional bias scores in both samples. This association was qualified by an interaction with stress in one sample, such that links between the S allele and decreased positive attentional bias was significant only when life stress was elevated. This difference in findings between the two samples was explained by sex differences in samples; the GXE interaction was significant only in boys. Findings are discussed in the context of sex differences in GXE.

Item Metadata

Title
The serotonin transporter promoter variant, stress, and attentional biases in middle childhood
Creator
Kotelnikova, Yuliya; LeMoult, Joelle; Mackrell, Sarah V. M.; Sheikh, Haroon I.; Singh, Shiva M.; Joormann, Jutta; Gotlib, Ian H.; Hayden, Elizabeth P.
Publisher
Elsevier
Date Issued
2016-06-20
Description
Although evidence suggests that 5-HTTLPR variants may shape risk for depression, the influence is likely complex, and involves effects on endophenotypes. We examined associations between 5-HTTLPR and biases in attention to affective stimuli in a sample of girls and a sample of both boys and girls. Children with at least one short (S) variant of the 5-HTTLPR polymorphism had lower positive attentional bias scores in both samples. This association was qualified by an interaction with stress in one sample, such that links between the S allele and decreased positive attentional bias was significant only when life stress was elevated. This difference in findings between the two samples was explained by sex differences in samples; the GXE interaction was significant only in boys. Findings are discussed in the context of sex differences in GXE.
Subject
Serotonin transporter promoter; Attentional biases; Middle childhood
Genre
Article
Type
Text
Language
eng
Date Available
2022-05-13
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International
DOI
10.14288/1.0413595
URI
http://hdl.handle.net/2429/81548
Affiliation
Non UBC; Arts, Faculty of; Psychology, Department of
Citation
Kotelnikova, Y., LeMoult, J., Mackrell, S. V. M., Sheikh, H. I., Singh, S. M., Joormann, J., Gotlib, I. H., & Hayden, E. P. (2016). The serotonin transporter promoter variant, stress, and attentional biases in middle childhood. Personality and Individual Differences, 101, 371–379
Publisher DOI
10.1016/j.paid.2016.06.004
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International