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The relation between age and airway epithelial barrier function de Vries, M.; Nwozor, K. O.; Muizer, K.; Wisman, M.; Timens, W.; van den Berge, M.; Faiz, A.; Hackett, Tillie-Louise; Heijink, I. H.; Brandsma, C. A.

Abstract

Background The prevalence of age-associated diseases, such as chronic obstructive pulmonary disease (COPD), is increasing as the average life expectancy increases around the world. We previously identified a gene signature for ageing in the human lung which included genes involved in apical and tight junction assembly, suggesting a role for airway epithelial barrier dysfunction with ageing. Aim To investigate the association between genes involved in epithelial barrier function and age both in silico and in vitro in the airway epithelium. Methods We curated a gene signature of 274 genes for epithelial barrier function and tested the association with age in two independent cohorts of bronchial brushings from healthy individuals with no respiratory disease, using linear regression analysis (FDR 

Item Metadata

Title
The relation between age and airway epithelial barrier function
Creator
de Vries, M.; Nwozor, K. O.; Muizer, K.; Wisman, M.; Timens, W.; van den Berge, M.; Faiz, A.; Hackett, Tillie-Louise; Heijink, I. H.; Brandsma, C. A.
Contributor
University of British Columbia. Centre for Heart Lung Innovation
Publisher
BioMed Central
Date Issued
2022-03-03
Description
Background The prevalence of age-associated diseases, such as chronic obstructive pulmonary disease (COPD), is increasing as the average life expectancy increases around the world. We previously identified a gene signature for ageing in the human lung which included genes involved in apical and tight junction assembly, suggesting a role for airway epithelial barrier dysfunction with ageing. Aim To investigate the association between genes involved in epithelial barrier function and age both in silico and in vitro in the airway epithelium. Methods We curated a gene signature of 274 genes for epithelial barrier function and tested the association with age in two independent cohorts of bronchial brushings from healthy individuals with no respiratory disease, using linear regression analysis (FDR 
Subject
Ageing; Epithelial barrier function; EPCAM; CDH1; Airway epithelial cells; Chronic airway diseases
Genre
Article
Type
Text
Language
eng
Date Available
2022-04-04
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0412173
URI
http://hdl.handle.net/2429/81079
Affiliation
Medicine, Faculty of; Non UBC; Anesthesiology, Pharmacology and Therapeutics, Department of
Citation
Respiratory Research. 2022 Mar 03;23(1):43
Publisher DOI
10.1186/s12931-022-01961-7
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)