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A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib Lim, Chloe A. R.; Banyi, Norbert; Tucker, Tracy; Ionescu, Diana N.; Melosky, Barbara

Abstract

We report a rare case of stage IV pulmonary combined large-cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma (ACA), both demonstrating anaplastic lymphoma kinase (ALK) rearrangement by IHC and FISH. This 61-year-old lifelong nonsmoking Asian woman presented with a cough, and after diagnosis and surgical treatment, completed four cycles of adjuvant cisplatin and etoposide chemotherapy. She subsequently developed recurrence with bony metastases of exclusively ALK-positive LCNEC. Alectinib was started, and the patient experienced a partial response.

Item Metadata

Title
A Case of ALK-Rearranged Combined Lung Adenocarcinoma and Neuroendocrine Carcinoma with Diffuse Bone Metastasis and Partial Response to Alectinib
Creator
Lim, Chloe A. R.; Banyi, Norbert; Tucker, Tracy; Ionescu, Diana N.; Melosky, Barbara
Contributor
BC Cancer Agency; University of British Columbia. Division of Medical Oncology
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2022-02-03
Description
We report a rare case of stage IV pulmonary combined large-cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma (ACA), both demonstrating anaplastic lymphoma kinase (ALK) rearrangement by IHC and FISH. This 61-year-old lifelong nonsmoking Asian woman presented with a cough, and after diagnosis and surgical treatment, completed four cycles of adjuvant cisplatin and etoposide chemotherapy. She subsequently developed recurrence with bony metastases of exclusively ALK-positive LCNEC. Alectinib was started, and the patient experienced a partial response.
Subject
neuroendocrine; adenocarcinoma; driver mutation; ALK; LCNEC
Genre
Article
Type
Text
Language
eng
Date Available
2022-03-22
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0407281
URI
http://hdl.handle.net/2429/80994
Affiliation
Medicine, Faculty of; Non UBC; Pathology and Laboratory Medicine, Department of
Citation
Current Oncology 29 (2): 848-852 (2022)
Publisher DOI
10.3390/curroncol29020072
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Undergraduate; Other
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0