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Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications Mousavi, Seyyed M.; Behbudi, Gity; Gholami, Ahmad; Hashemi, Seyyed Alireza; Nejad, Zohre M.; Bahrani, Sonia; Chiang, Wei-Hung; Wei, Lai C.; Omidifar, Navid

Abstract

Zinc nanostructures (ZnONSs) have attracted much attention due to their morphological, physicochemical, and electrical properties, which were entailed for various biomedical applications such as cancer and diabetes treatment, anti-inflammatory activity, drug delivery. ZnONS play an important role in inducing cellular apoptosis, triggering excess reactive oxygen species (ROS) production, and releasing zinc ions due to their inherent nature and specific shape. Therefore, several new synthetic organometallic method has been developed to prepare ZnO crystalline nanostructures with controlled size and shape. Zinc oxide nanostructures’ crystal size and shape can be controlled by simply changing the physical synthesis condition such as microwave irradiation time, reaction temperature, and TEA concentration at reflux. Physicochemical properties which are determined by the shape and size of ZnO nanostructures, directly affect their biological applications. These nanostructures can decompose the cell membrane and accumulate in the cytoplasm, which leads to apoptosis or cell death. In this study, we reviewed the various synthesis methods which affect the nano shapes of zinc particles, and physicochemical properties of zinc nanostructures that determined the shape of zinc nanomaterials. Also, we mentioned some macromolecules that controlled their physicochemical properties in a green and biological approaches. In addition, we present the recent progress of ZnONSs in the biomedical fields, which will help centralize biomedical fields and assist their future research development.

Item Metadata

Title
Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications
Creator
Mousavi, Seyyed M.; Behbudi, Gity; Gholami, Ahmad; Hashemi, Seyyed Alireza; Nejad, Zohre M.; Bahrani, Sonia; Chiang, Wei-Hung; Wei, Lai C.; Omidifar, Navid
Contributor
University of British Columbia. Nanomaterials and Polymer Nanocomposites Laboratory
Publisher
BioMed Central
Date Issued
2022-02-02
Description
Zinc nanostructures (ZnONSs) have attracted much attention due to their morphological, physicochemical, and electrical properties, which were entailed for various biomedical applications such as cancer and diabetes treatment, anti-inflammatory activity, drug delivery. ZnONS play an important role in inducing cellular apoptosis, triggering excess reactive oxygen species (ROS) production, and releasing zinc ions due to their inherent nature and specific shape. Therefore, several new synthetic organometallic method has been developed to prepare ZnO crystalline nanostructures with controlled size and shape. Zinc oxide nanostructures’ crystal size and shape can be controlled by simply changing the physical synthesis condition such as microwave irradiation time, reaction temperature, and TEA concentration at reflux. Physicochemical properties which are determined by the shape and size of ZnO nanostructures, directly affect their biological applications. These nanostructures can decompose the cell membrane and accumulate in the cytoplasm, which leads to apoptosis or cell death. In this study, we reviewed the various synthesis methods which affect the nano shapes of zinc particles, and physicochemical properties of zinc nanostructures that determined the shape of zinc nanomaterials. Also, we mentioned some macromolecules that controlled their physicochemical properties in a green and biological approaches. In addition, we present the recent progress of ZnONSs in the biomedical fields, which will help centralize biomedical fields and assist their future research development.
Subject
Shape controlled zinc oxide nanostructures; Biomedical applications; Reactive oxidative stress; Macromolecules
Genre
Article
Type
Text
Language
eng
Date Available
2022-02-17
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0406612
URI
http://hdl.handle.net/2429/80846
Affiliation
Applied Science, Faculty of; Non UBC; Engineering, School of (Okanagan)
Citation
Biomaterials Research. 2022 Feb 02;26(1):4
Publisher DOI
10.1186/s40824-022-00252-y
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)