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Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection : A Case Report Sherwood, Karen; Nicholl, David; Fenninger, Franz; Wu, Vivian; Wong, Paaksum; Benedicto, Vince; Cina, Davide; Wang, Meng; Pobran, Taylor; De Marco, Mari L; Jassem, Agatha; Sekirov, Inna; Morshed, Muhammad; Bardi, Mohammad; Sekhon, Mypinder S.; Keown, Paul A.; Kadatz, Matthew; Lan, James H.

Abstract

To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.

Item Metadata

Title
Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection : A Case Report
Creator
Sherwood, Karen; Nicholl, David; Fenninger, Franz; Wu, Vivian; Wong, Paaksum; Benedicto, Vince; Cina, Davide; Wang, Meng; Pobran, Taylor; De Marco, Mari L; Jassem, Agatha; Sekirov, Inna; Morshed, Muhammad; Bardi, Mohammad; Sekhon, Mypinder S.; Keown, Paul A.; Kadatz, Matthew; Lan, James H.
Contributor
BC Centre for Disease Control
Publisher
Frontiers Media
Date Issued
2021-09-22
Description
To date there is limited data on the immune profile and outcomes of solid organ transplant recipients who encounter COVID-19 infection early post-transplant. Here we present a unique case where the kidney recipient’s transplant surgery coincided with a positive SARS-CoV-2 test and the patient subsequently developed symptomatic COVID-19 perioperatively. We performed comprehensive immunological monitoring of cellular, proteomic, and serological changes during the first 4 critical months post-infection. We showed that continuation of basiliximab induction and maintenance of triple immunosuppression did not significantly impair the host’s ability to mount a robust immune response against symptomatic COVID-19 infection diagnosed within the first week post-transplant.
Subject
COVID-19; Transplant; Induction therapy; Immunosuppressants; Immune response
Genre
Article
Type
Text
Language
eng
Date Available
2021-10-27
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International
DOI
10.14288/1.0402654
URI
http://hdl.handle.net/2429/80095
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of; Pathology and Laboratory Medicine, Department of; Urologic Sciences, Department of
Citation
Sherwood KR, Nicholl DDM, Fenninger F, Wu V, Wong P, Benedicto V, Cina DP, Wang M, Pobran TD, De Marco ML, Ma´rquez AC, Jassem AN, Sekirov I, Morshed MG, Bardi M, Sekhon M, Keown P, Kadatz M and Lan JH (2021) Comprehensive Immune Profiling of a Kidney Transplant Recipient With Peri-Operative SARS-CoV-2 Infection: A Case Report. Front. Immunol. 12:753558.
Publisher DOI
10.3389/fimmu.2021.753558
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher; Postdoctoral; Graduate
Copyright Holder
Authors
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International