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Synovial sarcoma oncogenesis revealed by single-cell profiling Qiu, Alvin; Nielsen, Torsten

Abstract

Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.

Item Metadata

Title
Synovial sarcoma oncogenesis revealed by single-cell profiling
Creator
Qiu, Alvin; Nielsen, Torsten
Contributor
Vancouver Coastal Health Authority. Research Institute
Publisher
Elsevier
Date Issued
2021-06
Description
Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.
Subject
synovial sarcoma; epigenetics; single-cell; SS18-SSX; immune exclusion
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2022-06-01
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0402369
URI
http://hdl.handle.net/2429/79823
Affiliation
Medicine, Faculty of
Citation
Qiu A, Nielsen TO. Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling. Trends Cancer. 2021 Jun;7(6):482-483
Publisher DOI
10.1016/j.trecan.2021.03.002
Peer Review Status
Reviewed
Scholarly Level
Faculty; Graduate
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International