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The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis Gao, Chloe; Gupta, Saurabh; Adli, Taranah; Hou, Winston; Coolsaet, Reid; Hayes, Abigail; Kim, Kevin; Pandey, Arjun; Gordon, Jacob; Chahil, Gurneet; Belley-Cote, Emilie P.; Whitlock, Richard P.

Abstract

Background Nitrate supplementation is thought to improve performance in endurance sports. Objective To meta-analyze studies evaluating the effect of nitrate supplementation on endurance sports performance among adults. Data sources We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science and CINAHL without language restrictions. Methods We included studies that: 1) compared nitrate supplementation with placebo; 2) enrolled adults engaging in an endurance-based activity; and 3) reported a performance measure or surrogate physiologic outcome. We evaluated risk of bias using the Cochrane Collaboration tool and pooled data with a random-effects model. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to evaluate confidence in estimates. Results We included 73 studies (n = 1061). Nitrate supplementation improved power output (MD 4.6 watts, P < 0.0001), time to exhaustion (MD 25.3 s, P < 0.00001), and distance travelled (MD 163.7 m, P = 0.03). We found no significant difference on perceived exertion, time trial performance and work done. Nitrate supplementation decreased VO₂ (MD − 0.04 L/min, P < 0.00001) but had no significant effect on VO₂ₘₐₓ or blood lactate levels. Conclusion The available evidence suggests that dietary nitrate supplementation benefits performance-related outcomes for endurance sports.

Item Metadata

Title
The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis
Creator
Gao, Chloe; Gupta, Saurabh; Adli, Taranah; Hou, Winston; Coolsaet, Reid; Hayes, Abigail; Kim, Kevin; Pandey, Arjun; Gordon, Jacob; Chahil, Gurneet; Belley-Cote, Emilie P.; Whitlock, Richard P.
Publisher
BioMed Central
Date Issued
2021-07-09
Description
Background Nitrate supplementation is thought to improve performance in endurance sports. Objective To meta-analyze studies evaluating the effect of nitrate supplementation on endurance sports performance among adults. Data sources We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science and CINAHL without language restrictions. Methods We included studies that: 1) compared nitrate supplementation with placebo; 2) enrolled adults engaging in an endurance-based activity; and 3) reported a performance measure or surrogate physiologic outcome. We evaluated risk of bias using the Cochrane Collaboration tool and pooled data with a random-effects model. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to evaluate confidence in estimates. Results We included 73 studies (n = 1061). Nitrate supplementation improved power output (MD 4.6 watts, P < 0.0001), time to exhaustion (MD 25.3 s, P < 0.00001), and distance travelled (MD 163.7 m, P = 0.03). We found no significant difference on perceived exertion, time trial performance and work done. Nitrate supplementation decreased VO₂ (MD − 0.04 L/min, P < 0.00001) but had no significant effect on VO₂ₘₐₓ or blood lactate levels. Conclusion The available evidence suggests that dietary nitrate supplementation benefits performance-related outcomes for endurance sports.
Subject
Nitrate supplementation; Endurance exercise; Systematic review and meta-analysis
Genre
Article
Type
Text
Language
eng
Date Available
2021-07-12
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0400135
URI
http://hdl.handle.net/2429/78908
Affiliation
Medicine, Faculty of; Non UBC
Citation
Journal of the International Society of Sports Nutrition. 2021 Jul 09;18(1):55
Publisher DOI
10.1186/s12970-021-00450-4
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)