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Management strategies and clinical outcomes in breast cancer patients who develop left ventricular dysfunction during trastuzumab therapy Yao, Ren Jie Robert; Gibson, Jordan; Simmons, Christine; Davis, Margot K.

Abstract

Background: Trastuzumab reduces risk of breast cancer recurrence but carries risk of cardiotoxicity that may be reversible upon treatment cessation and institution of left ventricular (LV) enhancement therapies (LVETx). We assessed management patterns of trastuzumab-induced cardiotoxicity (TIC) in a contemporary real-world setting. Methods: We reviewed charts of all breast cancer patients who received adjuvant trastuzumab in British Columbia between January 2010 and December 2013, spanning the opening of a cardio-oncology clinic. LV dysfunction (LVD) was classified as minimal (LVEF nadir 45–49%), mild (40–44%) or moderate-severe (

Item Metadata

Title
Management strategies and clinical outcomes in breast cancer patients who develop left ventricular dysfunction during trastuzumab therapy
Creator
Yao, Ren Jie Robert; Gibson, Jordan; Simmons, Christine; Davis, Margot K.
Publisher
BioMed Central
Date Issued
2021-03-26
Description
Background: Trastuzumab reduces risk of breast cancer recurrence but carries risk of cardiotoxicity that may be reversible upon treatment cessation and institution of left ventricular (LV) enhancement therapies (LVETx). We assessed management patterns of trastuzumab-induced cardiotoxicity (TIC) in a contemporary real-world setting. Methods: We reviewed charts of all breast cancer patients who received adjuvant trastuzumab in British Columbia between January 2010 and December 2013, spanning the opening of a cardio-oncology clinic. LV dysfunction (LVD) was classified as minimal (LVEF nadir 45–49%), mild (40–44%) or moderate-severe (
Subject
Trastuzumab; Left ventricular dysfunction; Heart failure; Breast cancer
Genre
Article
Type
Text
Language
eng
Date Available
2021-03-31
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0396437
URI
http://hdl.handle.net/2429/77688
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
Cardio-Oncology. 2021 Mar 26;7(1):12
Publisher DOI
10.1186/s40959-021-00099-7
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Rights

Attribution 4.0 International (CC BY 4.0)