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The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis Shoucair, Issraa; Weber Mello, Fernanda; Jabalee, James; Maleki, Saeideh; Garnis, Cathie

Abstract

Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.

Item Metadata

Title
The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
Creator
Shoucair, Issraa; Weber Mello, Fernanda; Jabalee, James; Maleki, Saeideh; Garnis, Cathie
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2020-09-17
Description
Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.
Subject
extracellular vesicles; tumor microenvironment; cancer-associated fibroblasts; neoplasms
Genre
Article
Type
Text
Language
eng
Date Available
2020-09-29
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0394557
URI
http://hdl.handle.net/2429/76215
Affiliation
Medicine, Faculty of; Non UBC; Surgery, Department of
Citation
International Journal of Molecular Sciences 21 (18): 6837 (2020)
Publisher DOI
10.3390/ijms21186837
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
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CC BY 4.0