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Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry Won, Ki-Bum; Lee, Byoung K.; Park, Hyung-Bok; Heo, Ran; Lee, Sang-Eun; Rizvi, Asim; Lin, Fay Y.; Kumar, Amit; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji M.; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J.; Gottlieb, Ilan; Chun, Eun J.; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; de Araújo Gonçalves, Pedro; Leipsic, Jonathon; Shin, Sanghoon; Choi, Jung H.; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Raff, Gilbert L.; Stone, Peter H.; Berman, Daniel S.; Narula, Jagat; Shaw, Leslee J.; Bax, Jeroen J.; Min, James K.; Chang, Hyuk-Jae

Abstract

Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6–4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0–117.7), group II: 47.2 (6.2–160.4), and group III [highest]: 57.5 (8.4–154.3); P 

Item Metadata

Title
Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry
Creator
Won, Ki-Bum; Lee, Byoung K.; Park, Hyung-Bok; Heo, Ran; Lee, Sang-Eun; Rizvi, Asim; Lin, Fay Y.; Kumar, Amit; Hadamitzky, Martin; Kim, Yong-Jin; Sung, Ji M.; Conte, Edoardo; Andreini, Daniele; Pontone, Gianluca; Budoff, Matthew J.; Gottlieb, Ilan; Chun, Eun J.; Cademartiri, Filippo; Maffei, Erica; Marques, Hugo; de Araújo Gonçalves, Pedro; Leipsic, Jonathon; Shin, Sanghoon; Choi, Jung H.; Virmani, Renu; Samady, Habib; Chinnaiyan, Kavitha; Raff, Gilbert L.; Stone, Peter H.; Berman, Daniel S.; Narula, Jagat; Shaw, Leslee J.; Bax, Jeroen J.; Min, James K.; Chang, Hyuk-Jae
Publisher
BioMed Central
Date Issued
2020-07-18
Description
Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6–4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0–117.7), group II: 47.2 (6.2–160.4), and group III [highest]: 57.5 (8.4–154.3); P 
Subject
Triglyceride glucose index; Coronary artery disease; Atherosclerosis; Coronary computed tomography angiography
Genre
Article
Type
Text
Language
eng
Date Available
2020-07-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0392471
URI
http://hdl.handle.net/2429/75221
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of; Radiology, Department of
Citation
Cardiovascular Diabetology. 2020 Jul 18;19(1):113
Publisher DOI
10.1186/s12933-020-01081-w
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)