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Significance of body temperature in elderly patients with sepsis Shimazui, Takashi; Nakada, Taka-aki; Walley, Keith R. (Keith Robert); Oshima, Taku; Abe, Toshikazu; Ogura, Hiroshi; Shiraishi, Atsushi; Kushimoto, Shigeki; Saitoh, Daizoh; Fujishima, Seitaro; Mayumi, Toshihiko; Shiino, Yasukazu; Tarui, Takehiko; Hifumi, Toru; Otomo, Yasuhiro; Okamoto, Kohji; Umemura, Yutaka; Kotani, Joji; Sakamoto, Yuichiro; Sasaki, Junichi; Shiraishi, Shin-ichiro; Takuma, Kiyotsugu; Tsuruta, Ryosuke; Hagiwara, Akiyoshi; Yamakawa, Kazuma; Masuno, Tomohiko; Takeyama, Naoshi; Yamashita, Norio; Ikeda, Hiroto; Ueyama, Masashi; Fujimi, Satoshi; Gando, Satoshi

Abstract

Background: Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in elderly and non-elderly patients with sepsis. Methods: This was a retrospective observational study. A Japanese multicenter sepsis cohort (FORECAST, n = 1148) was used for the discovery analyses. Significant discovery results were tested for replication using two validation cohorts of sepsis (JAAMSR, Japan, n = 624; SPH, Canada, n = 1004). Patients were categorized into elderly and non-elderly groups (age ≥ 75 or

Item Metadata

Title
Significance of body temperature in elderly patients with sepsis
Creator
Shimazui, Takashi; Nakada, Taka-aki; Walley, Keith R. (Keith Robert); Oshima, Taku; Abe, Toshikazu; Ogura, Hiroshi; Shiraishi, Atsushi; Kushimoto, Shigeki; Saitoh, Daizoh; Fujishima, Seitaro; Mayumi, Toshihiko; Shiino, Yasukazu; Tarui, Takehiko; Hifumi, Toru; Otomo, Yasuhiro; Okamoto, Kohji; Umemura, Yutaka; Kotani, Joji; Sakamoto, Yuichiro; Sasaki, Junichi; Shiraishi, Shin-ichiro; Takuma, Kiyotsugu; Tsuruta, Ryosuke; Hagiwara, Akiyoshi; Yamakawa, Kazuma; Masuno, Tomohiko; Takeyama, Naoshi; Yamashita, Norio; Ikeda, Hiroto; Ueyama, Masashi; Fujimi, Satoshi; Gando, Satoshi
Contributor
University of British Columbia. Centre for Heart Lung Innovation
Publisher
BioMed Central
Date Issued
2020-06-30
Description
Background: Elderly patients have a blunted host response, which may influence vital signs and clinical outcomes of sepsis. This study was aimed to investigate whether the associations between the vital signs and mortality are different in elderly and non-elderly patients with sepsis. Methods: This was a retrospective observational study. A Japanese multicenter sepsis cohort (FORECAST, n = 1148) was used for the discovery analyses. Significant discovery results were tested for replication using two validation cohorts of sepsis (JAAMSR, Japan, n = 624; SPH, Canada, n = 1004). Patients were categorized into elderly and non-elderly groups (age ≥ 75 or
Subject
Septic shock; Elderly; Body temperature; Fever; Hypothermia
Genre
Article
Type
Text
Language
eng
Date Available
2020-07-02
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0392043
URI
http://hdl.handle.net/2429/74836
Affiliation
Other UBC; Non UBC
Citation
Critical Care. 2020 Jun 30;24(1):387
Publisher DOI
10.1186/s13054-020-02976-6
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s)
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)