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Transvaginal ovarian drilling followed by controlled ovarian stimulation from the next day improves ovarian response for the poor responders with polycystic ovary syndrome during IVF treatment: a pilot study Xu, Bufang; Zhou, Mingjuan; Cheng, Meiyu; Zhang, Dan; Wu, Xian; Si, Chenchen; Xia, Lan; Xu, Huihui; Li, Jian; Chang, Hsun-Ming; Leung, P. C. K.; Zhang, Aijun

Abstract

Background: Poor response patients with PCOS who are not susceptible to gonadotropin stimulation are more likely to have canceled cycles or poor clinical outcomes during IVF treatment. However, some limitations exist in the present therapies. In this study, we evaluated the effects of using the transvaginal ovarian drilling (TVOD) followed by controlled ovarian stimulation (COS) from the second day of these poor responders. Methods: During IVF, 7 poor responders with PCOS and 28 PCOS patients (14 normal and 14 high responders) were recruited. All patients received COS with the gonadotropin-releasing hormone antagonist protocol. For the poor responders, after undergoing 10 to 14 days of ovulation induction with no response, the TVOD was applied and then ovarian stimulation was performed from the next day at the same gonadotropin dose. Serum samples during COS and follicular fluid samples from the dominant follicles on the oocyte pick-up (OPU) day in all three groups were collected. Besides, follicular fluid from small follicles (diameter 

Item Metadata

Title
Transvaginal ovarian drilling followed by controlled ovarian stimulation from the next day improves ovarian response for the poor responders with polycystic ovary syndrome during IVF treatment: a pilot study
Creator
Xu, Bufang; Zhou, Mingjuan; Cheng, Meiyu; Zhang, Dan; Wu, Xian; Si, Chenchen; Xia, Lan; Xu, Huihui; Li, Jian; Chang, Hsun-Ming; Leung, P. C. K.; Zhang, Aijun
Contributor
Children's Hospital (Vancouver, B.C.)
Publisher
BioMed Central
Date Issued
2020-01-24
Description
Background: Poor response patients with PCOS who are not susceptible to gonadotropin stimulation are more likely to have canceled cycles or poor clinical outcomes during IVF treatment. However, some limitations exist in the present therapies. In this study, we evaluated the effects of using the transvaginal ovarian drilling (TVOD) followed by controlled ovarian stimulation (COS) from the second day of these poor responders. Methods: During IVF, 7 poor responders with PCOS and 28 PCOS patients (14 normal and 14 high responders) were recruited. All patients received COS with the gonadotropin-releasing hormone antagonist protocol. For the poor responders, after undergoing 10 to 14 days of ovulation induction with no response, the TVOD was applied and then ovarian stimulation was performed from the next day at the same gonadotropin dose. Serum samples during COS and follicular fluid samples from the dominant follicles on the oocyte pick-up (OPU) day in all three groups were collected. Besides, follicular fluid from small follicles (diameter 
Subject
Poor ovarian response; PCOS; TVOD; AMH; Testosterone; BMI
Genre
Article
Type
Text
Language
eng
Date Available
2020-01-27
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0388444
URI
http://hdl.handle.net/2429/73392
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Obstetrics and Gynaecology, Department of
Citation
Reproductive Biology and Endocrinology. 2020 Jan 24;18(1):7
Publisher DOI
10.1186/s12958-019-0559-7
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)