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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates Tomassetti, Mara; Lupidi, Gabriele; Piermattei, Pamela; Rossi, Federico V.; Lillini, Samuele; Bianchini, Gianluca; Aramini, Andrea; Ciufolini, Marco A.; Marcantoni, Enrico

Abstract

A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

Item Metadata

Title
Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates
Creator
Tomassetti, Mara; Lupidi, Gabriele; Piermattei, Pamela; Rossi, Federico V.; Lillini, Samuele; Bianchini, Gianluca; Aramini, Andrea; Ciufolini, Marco A.; Marcantoni, Enrico
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2019-10-25
Description
A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
Subject
α-chloroglycinates; 5-acylamino-1,3-thiazoles; Hantzsch reaction
Genre
Article
Type
Text
Language
eng
Date Available
2019-11-12
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0385172
URI
http://hdl.handle.net/2429/72260
Affiliation
Science, Faculty of; Non UBC; Chemistry, Department of
Citation
Molecules 24 (21): 3846 (2019)
Publisher DOI
10.3390/molecules24213846
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0