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Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols Weber, Patrick; Nasseri, Seyed A.; Pabst, Bettina M.; Torvisco, Ana; Müller, Philipp; Paschke, Eduard; Tschernutter, Marion; Windischhofer, Werner; Withers, Stephen G.; Wrodnigg, Tanja M.; Stütz, Arnold E.

Abstract

From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and may bear potential as regulators of N-acetyl-d-hexosaminidase activities in vivo.

Item Metadata

Title
Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
Creator
Weber, Patrick; Nasseri, Seyed A.; Pabst, Bettina M.; Torvisco, Ana; Müller, Philipp; Paschke, Eduard; Tschernutter, Marion; Windischhofer, Werner; Withers, Stephen G.; Wrodnigg, Tanja M.; Stütz, Arnold E.
Publisher
Multidisciplinary Digital Publishing Institute
Date Issued
2018-03-20
Description
From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and may bear potential as regulators of N-acetyl-d-hexosaminidase activities in vivo.
Subject
Aminocyclopentane; N-acetyl-d-hexosaminidase inhibitor; Tay-Sachs
Genre
Article
Type
Text
Language
eng
Date Available
2019-06-27
Provider
Vancouver : University of British Columbia Library
Rights
CC BY 4.0
DOI
10.14288/1.0379670
URI
http://hdl.handle.net/2429/70853
Affiliation
Science, Faculty of; Non UBC; Chemistry, Department of
Citation
Molecules 23 (3): 708 (2018)
Publisher DOI
10.3390/molecules23030708
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
https://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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CC BY 4.0