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Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm Wu, Yonghui; Lin, Xinyi; Lim, Ives Y.; Chen, Li; Teh, Ai L.; MacIsaac, Julia L.; Tan, Kok H.; Kobor, Michael S. (Geneticist); Chong, Yap S.; Gluckman, Peter D.; Karnani, Neerja

Abstract

Background: Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes. Thus, epigenome-wide association studies (EWAS), where DNAm sites are examined for associations with PTB, can help shed light on the biological mechanisms linking the two. Results: In an Asian cohort of 1019 infants (68 preterm, 951 full term), we examined and compared the associations between PTB and genome-wide DNAm profiles using both cord tissue (n = 1019) and cord blood (n = 332) samples on Infinium HumanMethylation450 arrays. PTB was significantly associated (P 

Item Metadata

Title
Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm
Creator
Wu, Yonghui; Lin, Xinyi; Lim, Ives Y.; Chen, Li; Teh, Ai L.; MacIsaac, Julia L.; Tan, Kok H.; Kobor, Michael S. (Geneticist); Chong, Yap S.; Gluckman, Peter D.; Karnani, Neerja
Contributor
University of British Columbia. Centre for Molecular Medicine and Therapeutics; Child and Family Research Institute
Publisher
BioMed Central
Date Issued
2019-02-11
Description
Background: Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes. Thus, epigenome-wide association studies (EWAS), where DNAm sites are examined for associations with PTB, can help shed light on the biological mechanisms linking the two. Results: In an Asian cohort of 1019 infants (68 preterm, 951 full term), we examined and compared the associations between PTB and genome-wide DNAm profiles using both cord tissue (n = 1019) and cord blood (n = 332) samples on Infinium HumanMethylation450 arrays. PTB was significantly associated (P 
Subject
Epigenome wide association study; Preterm birth; Gestational age; Tissue specificity; DNA methylation; Neonate
Genre
Article
Type
Text
Language
eng
Date Available
2019-02-11
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0376352
URI
http://hdl.handle.net/2429/68339
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medical Genetics, Department of
Citation
Clinical Epigenetics. 2019 Feb 11;11(1):26
Publisher DOI
10.1186/s13148-018-0599-4
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)