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Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsing–remitting multiple sclerosis at year 1 Traboulsee, Anthony; Li, David K. B.; Cascione, Mark; Fang, Juanzhi; Dangond, Fernando; Miller, Aaron

Abstract

Background: In the PRISMS study, interferon beta-1a subcutaneously (IFN β-1a SC) reduced clinical and radiological disease burden at 2 years in patients with relapsing–remitting multiple sclerosis. The study aimed to characterize efficacy of IFN β-1a SC 44 μg and 22 μg three times weekly (tiw) at Year 1. Methods: Exploratory endpoints included annualized relapse rate (ARR), 3-month confirmed disability progression (1-point Expanded Disability Status Scale increase if baseline was

Item Metadata

Title
Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsing–remitting multiple sclerosis at year 1
Creator
Traboulsee, Anthony; Li, David K. B.; Cascione, Mark; Fang, Juanzhi; Dangond, Fernando; Miller, Aaron
Publisher
BioMed Central
Date Issued
2018-09-14
Description
Background: In the PRISMS study, interferon beta-1a subcutaneously (IFN β-1a SC) reduced clinical and radiological disease burden at 2 years in patients with relapsing–remitting multiple sclerosis. The study aimed to characterize efficacy of IFN β-1a SC 44 μg and 22 μg three times weekly (tiw) at Year 1. Methods: Exploratory endpoints included annualized relapse rate (ARR), 3-month confirmed disability progression (1-point Expanded Disability Status Scale increase if baseline was
Subject
Relapsing–remitting multiple sclerosis; Clinical trials; Interferon-beta subcutaneously; Disability progression; MRI; No evidence of disease activity
Genre
Article
Type
Text
Language
eng
Date Available
2018-09-14
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0372053
URI
http://hdl.handle.net/2429/67185
Affiliation
Other UBC; Non UBC
Citation
BMC Neurology. 2018 Sep 14;18(1):143
Publisher DOI
10.1186/s12883-018-1145-x
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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Attribution 4.0 International (CC BY 4.0)