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Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease Shin, Sun H.; Park, Hye Y.; Kang, Danbee; Cho, Juhee; Kwon, Sung O.; Park, Joo H.; Lee, Jae S.; Oh, Yeon-Mok; Sin, Don D.; Kim, Woo J.; Lee, Sang-Do

Abstract

Background: Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association between the stability of blood eosinophils and long-term clinical outcomes in COPD patients has yet to be fully elucidated. This study aimed to evaluate the stability of blood eosinophils and its association with clinical outcomes in COPD patients. Methods: In total, 299 COPD patients from the Korean Obstructive Lung Disease cohort with at least two blood eosinophil measurements were included. Patients were stratified according to a cut-off of 300 cells/μL, and the association between eosinophil changes and all-cause mortality was analysed. The annual decline in forced expiratory volume in 1 s (FEV1), serial changes in St George’s Respiratory Questionnaire score (SGRQ), and exacerbations during follow-up were compared among eosinophil groups. Results: Patients were stratified into three groups according to the blood eosinophil cut-off: persistently

Item Metadata

Title
Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease
Creator
Shin, Sun H.; Park, Hye Y.; Kang, Danbee; Cho, Juhee; Kwon, Sung O.; Park, Joo H.; Lee, Jae S.; Oh, Yeon-Mok; Sin, Don D.; Kim, Woo J.; Lee, Sang-Do
Publisher
BioMed Central
Date Issued
2018-07-13
Description
Background: Blood eosinophils have been suggested as a potential biomarker in chronic obstructive pulmonary disease (COPD), and their stability over time has been investigated in a few studies. However, the association between the stability of blood eosinophils and long-term clinical outcomes in COPD patients has yet to be fully elucidated. This study aimed to evaluate the stability of blood eosinophils and its association with clinical outcomes in COPD patients. Methods: In total, 299 COPD patients from the Korean Obstructive Lung Disease cohort with at least two blood eosinophil measurements were included. Patients were stratified according to a cut-off of 300 cells/μL, and the association between eosinophil changes and all-cause mortality was analysed. The annual decline in forced expiratory volume in 1 s (FEV1), serial changes in St George’s Respiratory Questionnaire score (SGRQ), and exacerbations during follow-up were compared among eosinophil groups. Results: Patients were stratified into three groups according to the blood eosinophil cut-off: persistently
Subject
Chronic obstructive pulmonary disease; Eosinophil; Stability; Lung function
Genre
Article
Type
Text
Language
eng
Date Available
2018-07-16
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0368952
URI
http://hdl.handle.net/2429/66501
Affiliation
Medicine, Faculty of; Non UBC; Medicine, Department of
Citation
Respiratory Research. 2018 Jul 13;19(1):134
Publisher DOI
10.1186/s12931-018-0840-x
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)