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Effects of chronic estradiol, progesterone and medroxyprogesterone acetate on hippocampal neurogenesis and adrenal mass in adult female rats Chan, Melissa; Chow, Carmen; Hamson, Dwayne K.; Lieblich, Stephanie E.; Galea, Liisa A. M.

Abstract

Both natural estrogens and progesterone influence synaptic plasticity and neurogenesis within the female hippocampus. However, less is known of the impact of synthetic hormones on hippocampus structure and function. There is some evidence that administration of the synthetic progestin, medroxyprogesterone acetate (MPA) is not as beneficial as natural progesterone and can attenuate estrogen-induced neuroprotection. Although estradiol’s effects have been well studied, little is known about the effects of natural and synthetic progestins alone and in combination with estradiol on adult neurogenesis in the female. In the present study, we investigated the effects of chronic estradiol, progesterone, MPA, and a co-administration of each progestin with estradiol on neurogenesis within the dentate gyrus of adult ovariectomized female rats. Twenty-four hours following a bromodeoxyuridine (BrdU; 200mg/kg) injection, female rats were repeatedly administered with either progesterone (1 or 4 mg), MPA (1 or 4 mg), estradiol benzoate (EB), progesterone or MPA in combination with EB (10

Item Metadata

Title
Effects of chronic estradiol, progesterone and medroxyprogesterone acetate on hippocampal neurogenesis and adrenal mass in adult female rats
Creator
Chan, Melissa; Chow, Carmen; Hamson, Dwayne K.; Lieblich, Stephanie E.; Galea, Liisa A. M.
Publisher
Wiley
Date Issued
2014-06
Description
Both natural estrogens and progesterone influence synaptic plasticity and neurogenesis within the female hippocampus. However, less is known of the impact of synthetic hormones on hippocampus structure and function. There is some evidence that administration of the synthetic progestin, medroxyprogesterone acetate (MPA) is not as beneficial as natural progesterone and can attenuate estrogen-induced neuroprotection. Although estradiol’s effects have been well studied, little is known about the effects of natural and synthetic progestins alone and in combination with estradiol on adult neurogenesis in the female. In the present study, we investigated the effects of chronic estradiol, progesterone, MPA, and a co-administration of each progestin with estradiol on neurogenesis within the dentate gyrus of adult ovariectomized female rats. Twenty-four hours following a bromodeoxyuridine (BrdU; 200mg/kg) injection, female rats were repeatedly administered with either progesterone (1 or 4 mg), MPA (1 or 4 mg), estradiol benzoate (EB), progesterone or MPA in combination with EB (10
Genre
Article; Postprint
Type
Text
Language
eng
Date Available
2017-10-06
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0356561
URI
http://hdl.handle.net/2429/63210
Affiliation
Arts, Faculty of; Other UBC; Psychology, Department of
Citation
Chan, M., Chow, C., Hamson, D.K., Lieblich SE, Galea, L.A.M. (2014). Effects of chronic estradiol, progesterone and medroxyprogesterone acetate on hippocampal neurogenesis and adrenal mass in adult female rats. Journal of Neuroendocrinology [CIHR] 26(6):386-99
Publisher DOI
10.1111/jne.12159
Peer Review Status
Reviewed
Scholarly Level
Faculty
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
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DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International