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Lipoprotein (a), an independent cardiovascular risk marker Saeedi, Ramesh; Frohlich, Jiri

Abstract

Epidemiological and genetic studies have identified elevated levels of lipoprotein (a) ((Lp(a)) as a causal and independent risk factor for cardiovascular diseases (CVD). The Lp(a)-induced increased risk of CVD may be mediated by both its proatherogenic and prothrombotic mechanisms. Several guidelines recommend screening of Lp(a) level; however, there are few treatment options for the management of patients with elevated Lp(a). Several new medications for Lp(a) are under development. PCSK9 inhibitors, apolipoprotein (a)-antisense, and apolipoprotein(B-100)-antisense mipomersen have shown promising results. Lp(a) reduction will continue to be an active area of investigation.

Item Metadata

Title
Lipoprotein (a), an independent cardiovascular risk marker
Creator
Saeedi, Ramesh; Frohlich, Jiri
Contributor
St. Paul's Hospital (Vancouver, B.C.)
Publisher
BioMed Central
Date Issued
2016-03-31
Description
Epidemiological and genetic studies have identified elevated levels of lipoprotein (a) ((Lp(a)) as a causal and independent risk factor for cardiovascular diseases (CVD). The Lp(a)-induced increased risk of CVD may be mediated by both its proatherogenic and prothrombotic mechanisms. Several guidelines recommend screening of Lp(a) level; however, there are few treatment options for the management of patients with elevated Lp(a). Several new medications for Lp(a) are under development. PCSK9 inhibitors, apolipoprotein (a)-antisense, and apolipoprotein(B-100)-antisense mipomersen have shown promising results. Lp(a) reduction will continue to be an active area of investigation.
Subject
Lipoprotein(a) [Lp(a)]; Coronary artery disease (CAD); Niacin; Statins
Genre
Article
Type
Text
Language
eng
Date Available
2017-05-08
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0347343
URI
http://hdl.handle.net/2429/61562
Affiliation
Medicine, Faculty of; Other UBC; Pathology and Laboratory Medicine, Department of
Citation
Clinical Diabetes and Endocrinology. 2016 Mar 31;2(1):7
Publisher DOI
10.1186/s40842-016-0024-x
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Saeedi and Frohlich.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)