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The impact of methadone maintenance therapy on heptatis c incidence among illicit drug users Nolan, Seonaid; Dias Lima, Viviane; Fairbairn, Nadia; Kerr, Thomas; Montaner, Julio; Grebely, Jason; Wood, Evan
Abstract
Aims To determine the relationship between methadone maintenance therapy (MMT) and hepatitis C (HCV) seroconversion among illicit drug users. Design Generalized Estimating Equation model assuming a binomial distribution and a logit link function was used to examine for a possible protective effect of MMT use on HCV incidence. Setting Data from three prospective cohort studies of illicit drug users in Vancouver, Canada between 1996 and 2012. Participants 1004 HCV antibody negative illicit drug users stratified by exposure to MMT. Measurements Baseline and semi-annual HCV antibody testing and standardised interviewer administered questionnaire soliciting self-reported data relating to drug use patterns, risk behaviours, detailed sociodemographic data and status of active participation in an MMT program. Findings 184 HCV seroconversions were observed for an HCV incidence density of 6.32 [95% confidence interval [CI]: 5.44 – 7.31] per 100 person-years. After adjusting for potential confounders, MMT exposure was protective against HCV seroconversion (Adjusted Odds Ratio [AOR] = 0.47; 95% CI: 0.29 - 0.76). In sub-analyses, a dose-response protective effect of increasing MMT exposure on HCV incidence (AOR = 0.87; 95% CI: 0.78 – 0.97) per increasing 6-month period exposed to MMT was observed. Conclusion Participation in methadone maintenance treatment appears to be highly protective against hepatitis C incidence among illicit drug users. There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.
Item Metadata
| Title |
The impact of methadone maintenance therapy on heptatis c incidence among illicit drug users
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| Creator | |
| Contributor | |
| Date Issued |
2014-08-14
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| Description |
Aims
To determine the relationship between methadone maintenance therapy (MMT) and hepatitis C (HCV) seroconversion among illicit drug users.
Design
Generalized Estimating Equation model assuming a binomial distribution and a logit link function was used to examine for a possible protective effect of MMT use on HCV incidence.
Setting
Data from three prospective cohort studies of illicit drug users in Vancouver, Canada between 1996 and 2012.
Participants
1004 HCV antibody negative illicit drug users stratified by exposure to MMT.
Measurements
Baseline and semi-annual HCV antibody testing and standardised interviewer administered questionnaire soliciting self-reported data relating to drug use patterns, risk behaviours, detailed sociodemographic data and status of active participation in an MMT program.
Findings
184 HCV seroconversions were observed for an HCV incidence density of 6.32 [95% confidence interval [CI]: 5.44 – 7.31] per 100 person-years. After adjusting for potential confounders, MMT exposure was protective against HCV seroconversion (Adjusted Odds Ratio [AOR] = 0.47; 95% CI: 0.29 - 0.76). In sub-analyses, a dose-response protective effect of increasing MMT exposure on HCV incidence (AOR = 0.87; 95% CI: 0.78 – 0.97) per increasing 6-month period exposed to MMT was observed.
Conclusion
Participation in methadone maintenance treatment appears to be highly protective against hepatitis C incidence among illicit drug users. There appears to be a dose-response protective effect of increasing methadone exposure on hepatitis C incidence.
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| Subject | |
| Geographic Location | |
| Genre | |
| Type | |
| Language |
eng
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| Date Available |
2017-01-23
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| Provider |
Vancouver : University of British Columbia Library
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| Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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| DOI |
10.14288/1.0340656
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| URI | |
| Affiliation | |
| Citation |
Nolan, S., Lima, V. D., Fairbairn, N., Kerr, T., Montaner, J., Grebely, J., & Wood, E. (2014). The impact of methadone maintenance therapy on heptatis c incidence among illicit drug users. Addiction (Abingdon, England), 109(12), 2053–2059
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| Publisher DOI |
10.1111/add.12682
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| Peer Review Status |
Reviewed
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| Scholarly Level |
Faculty; Researcher; Graduate
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| Rights URI | |
| Aggregated Source Repository |
DSpace
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Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International