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Biological function of Presenilin and its role in AD pathogenesis Zhang, Shuting; Zhang, Mingming; Cai, Fang; Song, Weihong

Abstract

Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components – presenilins and their biological functions and contributions to the AD pathogenesis. The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones. The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch; the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway, regulating calcium homeostasis and their interaction with synaptic transmission.

Item Metadata

Title
Biological function of Presenilin and its role in AD pathogenesis
Creator
Zhang, Shuting; Zhang, Mingming; Cai, Fang; Song, Weihong
Contributor
Djavad Mowafaghian Centre for Brain Health
Publisher
BioMed Central
Date Issued
2013-07-17
Description
Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components – presenilins and their biological functions and contributions to the AD pathogenesis. The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones. The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch; the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway, regulating calcium homeostasis and their interaction with synaptic transmission.
Genre
Article
Type
Text
Language
eng
Date Available
2015-08-19
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0228463
URI
http://hdl.handle.net/2429/54523
Affiliation
Psychiatry, Department of; Non UBC; Medicine, Faculty of
Citation
Translational Neurodegeneration. 2013 Jul 17;2(1):15
Publisher DOI
10.1186/2047-9158-2-15
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Zhang et al.; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)