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Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon Dirks, Rachel C; Richard, Jeffrey S; Fearon, Angela M; Scott, Alexander; Koch, Lauren G; Britton, Steven L; Warden, Stuart J

Abstract

Background: The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Methods: Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis. Results: There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14). Conclusions: Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.

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Title
Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon
Creator
Dirks, Rachel C; Richard, Jeffrey S; Fearon, Angela M; Scott, Alexander; Koch, Lauren G; Britton, Steven L; Warden, Stuart J
Publisher
BioMed Central
Date Issued
2013-03-11
Description
Background: The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans. Methods: Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis. Results: There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14). Conclusions: Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.
Subject
Animal model; Tendinitis; Tendinopathy; Tendinosis; Overuse
Genre
Article
Type
Text
Language
eng
Date Available
2016-01-27
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0223793
URI
http://hdl.handle.net/2429/56751
Affiliation
Medicine, Faculty of; Physical Therapy, Department of; Non UBC
Citation
BMC Musculoskeletal Disorders. 2013 Mar 11;14(1):90
Publisher DOI
10.1186/1471-2474-14-90
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Dirks et al; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)