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Putting the pH into phosphatidic acid signaling Shin, John J; Loewen, Christopher J

Abstract

Abstract: The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.

Item Metadata

Title
Putting the pH into phosphatidic acid signaling
Creator
Shin, John J; Loewen, Christopher J
Contributor
University of British Columbia. Life Sciences Institute
Publisher
BioMed Central
Date Issued
2011-12-02
Description
Abstract: The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.
Genre
Article
Type
Text
Language
eng
Date Available
2015-12-16
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0221315
URI
http://hdl.handle.net/2429/55836
Affiliation
Cellular and Physiological Sciences, Department of; Medicine, Faculty of
Citation
BMC Biology. 2011 Dec 02;9(1):85
Publisher DOI
10.1186/1741-7007-9-85
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Shin and Loewen; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
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Rights

Attribution 4.0 International (CC BY 4.0)