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Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study Sulistyoningrum, Dian C.; Gasevic, Danijela; Lear, Scott A.; Ho, Joe; Mente, Andrew; Devlin, Angela M.

Abstract

Background: Ethnic-specific differences in insulin resistance (IR) are well described but the underlying mechanisms are unknown. Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) adiponectin associated with greatest insulin sensitivity. The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR. Methods Healthy Canadian Aboriginal, Chinese, European, and South Asian adults (N = 634) were assessed for sociodemographics; lifestyle; fasting plasma insulin, glucose, and total and HMW adiponectin; and adiposity measures [BMI, waist circumference, waist-to-hip ratio, percent body fat, and subcutaneous and visceral adipose tissue (quantified by computed tomography)]. The homeostasis model assessment-insulin resistance (HOMA-IR) assessed IR. Results South Asians had the greatest HOMA-IR, followed by Aboriginals, Chinese, and Europeans (P 

Item Metadata

Title
Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study
Creator
Sulistyoningrum, Dian C.; Gasevic, Danijela; Lear, Scott A.; Ho, Joe; Mente, Andrew; Devlin, Angela M.
Contributor
Child and Family Research Institute
Publisher
BioMed Central
Date Issued
2013-11-13
Description
Background: Ethnic-specific differences in insulin resistance (IR) are well described but the underlying mechanisms are unknown. Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) adiponectin associated with greatest insulin sensitivity. The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR. Methods Healthy Canadian Aboriginal, Chinese, European, and South Asian adults (N = 634) were assessed for sociodemographics; lifestyle; fasting plasma insulin, glucose, and total and HMW adiponectin; and adiposity measures [BMI, waist circumference, waist-to-hip ratio, percent body fat, and subcutaneous and visceral adipose tissue (quantified by computed tomography)]. The homeostasis model assessment-insulin resistance (HOMA-IR) assessed IR. Results South Asians had the greatest HOMA-IR, followed by Aboriginals, Chinese, and Europeans (P 
Subject
High molecular weight adiponectin; Ethnicity; Insulin resistance; Visceral adipose tissue
Genre
Article
Type
Text
Language
eng
Date Available
2015-11-04
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0215999
URI
http://hdl.handle.net/2429/55253
Affiliation
Medicine, Faculty of; Pediatrics, Department of; Non UBC
Citation
Cardiovascular Diabetology. 2013 Nov 13;12(1):170
Publisher DOI
10.1186/1475-2840-12-170
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
Sulistyoningrum et al.; licensee BioMed Central Ltd.
Rights URI
http://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International (CC BY 4.0)