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Using Best Evidence for the Management of Hypertension University of British Columbia. Therapeutics Initiative

Description

Therapeutics Letter 106 examines Cochrane systematic review evidence on antihypertensives for treatment of high blood pressure. Conclusions: Antihypertensive drug treatment modestly reduces mortality and morbidity in people ≥ 60 with moderate to severe hypertension (>160/100). Low-dose thiazide diuretics are the best drug class for starting therapy. In mild hypertension (140-159/90-99) antihypertensive drugs have not been proven to reduce mortality and morbidity. Blood pressure treatment targets should be those used in RCTs (<140-160/90-100), as lower BP targets have not been shown to have a net health benefit.

Item Metadata

Title
Using Best Evidence for the Management of Hypertension
Alternate Title
Therapeutics Letter 106
Creator
University of British Columbia. Therapeutics Initiative
Date Issued
2017-06
Description
Therapeutics Letter 106 examines Cochrane systematic review evidence on antihypertensives for treatment of high blood pressure. Conclusions: Antihypertensive drug treatment modestly reduces mortality and morbidity in people ≥ 60 with moderate to severe hypertension (>160/100). Low-dose thiazide diuretics are the best drug class for starting therapy. In mild hypertension (140-159/90-99) antihypertensive drugs have not been proven to reduce mortality and morbidity. Blood pressure treatment targets should be those used in RCTs (<140-160/90-100), as lower BP targets have not been shown to have a net health benefit.
Subject
Antihypertensive Agents; Blood Pressure; Diuretics; Hypertension; Morbidity; Mortality; Sodium Chloride Symporter Inhibitors; Thiazides
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433685
URI
http://hdl.handle.net/2429/85095
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International