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Is cyclobenzaprine useful for pain? University of British Columbia. Therapeutics Initiative

Description

Therapeutics Letter 105 considers the harms and benefits of cyclobenzaprine for pain. Conclusions: In B.C. cyclobenzaprine is prescribed for acute pain at higher doses and for longer durations than necessary, and is frequently prescribed for unapproved long term use. There is no compelling evidence that cyclobenzaprine is a muscle-relaxant. Effects on pain or overall function are likely the result of sedation. If prescribed, a dose of 5 mg at bedtime should be tried first. Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week.

Item Metadata

Title
Is cyclobenzaprine useful for pain?
Alternate Title
Therapeutics Letter 105
Creator
University of British Columbia. Therapeutics Initiative
Date Issued
2017-04
Description
Therapeutics Letter 105 considers the harms and benefits of cyclobenzaprine for pain. Conclusions: In B.C. cyclobenzaprine is prescribed for acute pain at higher doses and for longer durations than necessary, and is frequently prescribed for unapproved long term use. There is no compelling evidence that cyclobenzaprine is a muscle-relaxant. Effects on pain or overall function are likely the result of sedation. If prescribed, a dose of 5 mg at bedtime should be tried first. Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week.
Subject
Acute Pain; Adverse Effects; Analgesics; Cyclobenzaprine; Fibromyalgia; Treatment Outcome
Genre
Other
Type
Text
Language
eng
Notes
The UBC TI is funded by the BC Ministry of Health to provide evidence-based information about drug therapy. We neither formulate nor adjudicate provincial drug policies.
Date Available
2023-06-20
Provider
Vancouver : University of British Columbia Library
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
DOI
10.14288/1.0433684
URI
http://hdl.handle.net/2429/85094
Affiliation
Medicine, Faculty of; Anesthesiology, Pharmacology and Therapeutics, Department of
Peer Review Status
Reviewed
Scholarly Level
Faculty; Researcher
Rights URI
http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository
DSpace

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Attribution-NonCommercial-NoDerivatives 4.0 International