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Chapman, Judith-Anne W.; Liu, Shuzhen; Leung, Samuel; Nielsen, Torsten

Elsevier

Background: PAM50 intrinsic subtypes have been shown to impact breast cancer prognosis. Methods: A British Columbia cohort of 718 post-menopausal women treated with tamoxifen, without chemotherapy, had tumours intrinsic-subtyped (Luminal A;Luminal B;Basal;HER2) and centrally-reviewed by immunohistochemical (IHC) for estrogen and progesterone receptor (ER and PgR). We tested whether intrinsic subtype and other patient and tumour characteristics were associated with type of death. Results: At median 11.7 years follow-up, 429 of 718 (60%) women died: 30% of deaths were breast cancer-specific (BrCa); 30%, other type (OT). In 425 women <70 years, 32% died of BrCa and 19% of OT. In 293 >70, 27% died of BrCa and 45% of OT. Intrinsic subtype was associated with BrCa (p=0.001); and older age, with OT (p<0.001). Additionally, step-wise cause-specific models indicated larger tumour size (p<0.001), more positive lymph nodes (p<0.001), and less PgR stain (p=0.03) were associated with worse BrCa survival; more positive lymph nodes (p=0.002) and lymphovascular invasion (p=0.02) were associated with worse OT. Adjusted BrCa and OT survival is provided by factor at 5-, 10-, and 15-years. Conclusions: Intrinsic subtype was associated with BrCa death while age was associated with OT, the majority of deaths in women >70 being from OT.

Article; Postprint

eng

Vancouver : University of British Columbia Library

10.14288/1.0406153

Medicine, Faculty of; Non UBC; Pathology and Laboratory Medicine, Department of

10.1016/j.clbc.2017.01.002

Faculty; Other

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