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Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV) Xu, Stella; Vucic, Emily A.; Shaipanich, Tawimas; Lam, Stephen; Lam, Wan; Montaner, Julio; Sin, Don D.; Man, S. F. P.; Leung, Janice M.

Abstract

Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated that decreased peripheral leukocyte telomere length is associated with HIV, suggesting an accelerated aging phenomenon. We demonstrate that this process of telomere shortening also occurs in the lungs, with significant decreases in telomere length observed in small airway epithelial cells collected during bronchoscopy. Molecular evidence of accelerated aging in the small airway epithelium of persons living with HIV may be one clue into the predisposition for chronic lung disease observed in this population.

Item Metadata

Title
Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)
Creator
Xu, Stella; Vucic, Emily A.; Shaipanich, Tawimas; Lam, Stephen; Lam, Wan; Montaner, Julio; Sin, Don D.; Man, S. F. P.; Leung, Janice M.
Contributor
University of British Columbia. Centre for Heart Lung Innovation; British Columbia Centre for Excellence in HIV/AIDS
Publisher
BioMed Central
Date Issued
2018-06-13
Description
Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated that decreased peripheral leukocyte telomere length is associated with HIV, suggesting an accelerated aging phenomenon. We demonstrate that this process of telomere shortening also occurs in the lungs, with significant decreases in telomere length observed in small airway epithelial cells collected during bronchoscopy. Molecular evidence of accelerated aging in the small airway epithelium of persons living with HIV may be one clue into the predisposition for chronic lung disease observed in this population.
Subject
HIV; Telomere length; Epithelial cell
Genre
Article
Type
Text
Language
eng
Date Available
2018-06-13
Provider
Vancouver : University of British Columbia Library
Rights
Attribution 4.0 International (CC BY 4.0)
DOI
10.14288/1.0368662
URI
http://hdl.handle.net/2429/66293
Affiliation
Medicine, Faculty of; Other UBC; Non UBC; Medicine, Department of; Respiratory Medicine, Division of
Citation
Respiratory Research. 2018 Jun 13;19(1):117
Publisher DOI
10.1186/s12931-018-0821-0
Peer Review Status
Reviewed
Scholarly Level
Faculty
Copyright Holder
The Author(s).
Rights URI
http://creativecommons.org/licenses/by/4.0/
Aggregated Source Repository
DSpace

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Attribution 4.0 International (CC BY 4.0)