- Library Home /
- Search Collections /
- Open Collections /
- Browse Collections /
- UBC Faculty Research and Publications /
- Molecularly Defined Adult Granulosa Cell Tumor of the...
Open Collections
UBC Faculty Research and Publications
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary : the clinical phenotype McConechy, Melissa K.; Färkkilä, Anniina; Horlings, Hugo M.; Talhouk, Aline; Unkila-Kallio, Leila; van Meurs, Hannah S.; Yang, Winnie; Rozenberg, Nirit; Andersson, Noora; Zaby, Katharina; et al.
Abstract
The histopathologic features of Adult Granulosa Cell Tumors (AGCTs) are relatively non-specific, resulting in misdiagnosis of other cancers as AGCT, a problem that has not been well characterized. FOXL2 mutation testing was used to stratify 336 AGCTs from three European centers into three categories: 1) FOXL2 mutant molecularly defined AGCT (MD-AGCT)(n=256 of 336), 2) FOXL2 wild-type AGCT (n=17 of 336), 3) misdiagnosed other tumor types (n=63 of 336). All statistical tests were two-sided. The overall and disease-specific survival of the misdiagnosed cases was lower than in the MD-AGCTs (P<0.001). The misdiagnosed cases accounted for 71.9% of disease-specific deaths within five years. In the population-based cohort, overall survival of MD-AGCT patients was not different from age-matched population-based controls. Even though 35.2% of all the MD-AGCT patients, in our study, experienced a relapse, AGCT is usually an indolent disease. The historical, pre-molecular data underpinning our clinical understanding of AGCT was likely skewed by inclusion of misdiagnosed cases, and future management strategies should reflect the potential for surgical cure and long survival even after relapse.
Item Metadata
Title |
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary : the clinical phenotype
|
Creator |
McConechy, Melissa K.; Färkkilä, Anniina; Horlings, Hugo M.; Talhouk, Aline; Unkila-Kallio, Leila; van Meurs, Hannah S.; Yang, Winnie; Rozenberg, Nirit; Andersson, Noora; Zaby, Katharina; Bryk, Saara; Bützow, Ralf; Kommoss, Friedrich; Halfwerk, Johannes B.G.; Hooijer, Gerrit K.J.; van de Vijver, Marc J.; Buist, Marrije R.; Kenter, Gemma G.; Brucker, Sara Y.; Kraemer, Bernhard; Staebler, Annette; Bleeker, Maaike C.G.; Heikinheimo, Markku; Kommoss, Stefan; Gilks, C. Blake; Anttonen, Mikko; Huntsman, David G.
|
Date Issued |
2016
|
Description |
The histopathologic features of Adult Granulosa Cell Tumors (AGCTs) are relatively non-specific, resulting in misdiagnosis of other cancers as AGCT, a problem that has not been well characterized. FOXL2 mutation testing was used to stratify 336 AGCTs from three European centers into three categories: 1) FOXL2 mutant molecularly defined AGCT (MD-AGCT)(n=256 of 336), 2) FOXL2 wild-type AGCT (n=17 of 336), 3) misdiagnosed other tumor types (n=63 of 336). All statistical tests were two-sided. The overall and disease-specific survival of the misdiagnosed cases was lower than in the MD-AGCTs (P<0.001). The misdiagnosed cases accounted for 71.9% of disease-specific deaths within five years. In the population-based cohort, overall survival of MD-AGCT patients was not different from age-matched population-based controls. Even though 35.2% of all the MD-AGCT patients, in our study, experienced a relapse, AGCT is usually an indolent disease. The historical, pre-molecular data underpinning our clinical understanding of AGCT was likely skewed by inclusion of misdiagnosed cases, and future management strategies should reflect the potential for surgical cure and long survival even after relapse.
|
Subject | |
Genre | |
Type | |
Language |
eng
|
Date Available |
2017-06-13
|
Provider |
Vancouver : University of British Columbia Library
|
Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
|
DOI |
10.14288/1.0314929
|
URI | |
Affiliation | |
Citation |
McConechy, M. K., Färkkilä, A., Horlings, H. M., Talhouk, A., Unkila-Kallio, L., van Meurs, H. S., . . . Huntsman, D. G. (2016). Molecularly defined adult granulosa cell tumor of the ovary: The clinical phenotype. Journal of the National Cancer Institute, 108(11), djw134.
|
Publisher DOI |
10.1093/jnci/djw134
|
Peer Review Status |
Reviewed
|
Scholarly Level |
Faculty; Postdoctoral; Graduate; Other
|
Rights URI | |
Aggregated Source Repository |
DSpace
|
Item Media
Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International