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Mathematical Modeling of the Immune-Mediated Theory of Metastasis Hillen, Thomas
Description
Accumulating experimental and clinical evidence suggests that the immune response to cancer is not exclusively anti-tumor. In fact, several pro-tumor effects of the immune system have been identified, such as production of growth factors, establishment of angiogenesis, inhibition of immune response, initiation of cell movement and metastasis, and establishment of metastatic niches. Based on experimental data, we develop a mathematical model for the immune-mediated theory of metastasis, which includes anti- and pro-tumor effects of the immune system. The immune-mediated theory of metastasis can explain dormancy of metastasis and metastatic blow-up after resection of the primary tumor. It can explain increased metastasis at sites of injury, and the relatively poor performance of Immunotherapies, due to pro-tumor effects of the immune system. Our results suggest that further work is warranted to fully elucidate and control the pro-tumor effects of the immune system in metastatic cancer. (with Adam Rhodes).
Item Metadata
Title |
Mathematical Modeling of the Immune-Mediated Theory of Metastasis
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Creator | |
Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
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Date Issued |
2019-06-21T10:50
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Description |
Accumulating experimental and clinical evidence suggests that the immune response to cancer is not exclusively anti-tumor. In fact, several pro-tumor effects of the immune system have been identified, such as production of growth factors, establishment of angiogenesis, inhibition of immune response, initiation of cell movement and metastasis, and establishment of metastatic niches.
Based on experimental data, we develop a mathematical model for the immune-mediated theory of metastasis, which includes anti- and pro-tumor effects of the immune system. The immune-mediated theory of metastasis can explain dormancy of metastasis and metastatic blow-up after resection of the primary tumor. It can explain increased metastasis at sites of injury, and the relatively poor performance of Immunotherapies, due to pro-tumor effects of the immune system.
Our results suggest that further work is warranted to fully elucidate and control the pro-tumor effects of the immune system in metastatic cancer. (with Adam Rhodes).
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Extent |
35.0 minutes
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Subject | |
Type | |
File Format |
video/mp4
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Language |
eng
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Notes |
Author affiliation: University of Alberta
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Series | |
Date Available |
2020-09-08
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0394232
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URI | |
Affiliation | |
Peer Review Status |
Unreviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International