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Transient compartmentalization and its associated error thresholds Peliti, Luca
Description
A recently proposed mechanism suggests that transient compartmentalization could have preceded cell division in prebiotic scenarios. Here, we study various classes of transient compartmentalization dynamics. We show that two regimes are possible: In a diffusion-limited regime (e.g. simple autocatalysis), a large noise is generated at the population level due to asynchronous growth. In contrast, in a replication-limited regime with many steps (e.g. polymerization), a low noise is generated at the population level. Since strong noise will yield many unviable population compositions, polymerization can present a strong fitness advantage. For deterministic growth dynamics, we introduce mutations that turn functional replicators into parasites. This can either lead to coexistence or parasite dominance, and we derive the phase boundary separating these two phases as a function of relative growth, inoculation size and mutation rate. We show that transient compartmentalization allows coexistence beyond the classical error threshold.
Item Metadata
Title |
Transient compartmentalization and its associated error thresholds
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Creator | |
Publisher |
Banff International Research Station for Mathematical Innovation and Discovery
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Date Issued |
2019-08-21T11:11
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Description |
A recently proposed mechanism suggests that transient compartmentalization could have preceded cell division in prebiotic scenarios. Here, we study various classes of transient compartmentalization dynamics. We show that two regimes are possible: In a diffusion-limited regime (e.g. simple autocatalysis), a large noise is generated at the population level due to asynchronous growth. In contrast, in a replication-limited regime with many steps (e.g. polymerization), a low noise is generated at the population level. Since strong noise will yield many unviable population compositions, polymerization can present a strong fitness advantage. For deterministic growth dynamics, we introduce mutations that turn functional replicators into parasites. This can either lead to coexistence or parasite dominance, and we derive the phase boundary separating these two phases as a function of relative growth, inoculation size and mutation rate. We show that transient compartmentalization allows coexistence beyond the classical error threshold.
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Extent |
24.0 minutes
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Subject | |
Type | |
File Format |
video/mp4
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Language |
eng
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Notes |
Author affiliation: SMRI (Italy)
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Series | |
Date Available |
2020-02-18
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Provider |
Vancouver : University of British Columbia Library
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Rights |
Attribution-NonCommercial-NoDerivatives 4.0 International
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DOI |
10.14288/1.0388651
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URI | |
Affiliation | |
Peer Review Status |
Unreviewed
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Scholarly Level |
Faculty
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Rights URI | |
Aggregated Source Repository |
DSpace
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Item Citations and Data
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International