Title	Ductal Microinvasions: Cell and Matrix Interactions in Normal and Cancerous Tissues
Creator	Rejniak, Katarzyna
Publisher	Banff International Research Station for Mathematical Innovation and Discovery
Date Issued	2019-06-21T08:32
Description	Progression from a ductal carcinoma in situ (DCIS) to an invasive tumor is a major step initiating a devastating and often lethal metastatic cascade. We will discuss biological events leading to the formation of small invasive cohorts streaming from the DCIS. Using mathematical models on micro- and macro-scales integrated with information extracted from patientsÃ¢ histology samples, we investigated how changes in the local microenvironmental niche near the DCIS edge enable initiation and progression of ductal microinvasions. Of particular interest are the biomechanical interactions between the cells and the ECM fiber structure, and microenvironmental features that define tumor niche prone to microinvasions.
Extent	36.0 minutes
Subject	Mathematics; Biology and other natural sciences; Partial differential equations; Mathematical biology
Type	Moving Image
File Format	video/mp4
Language	eng
Notes	Author affiliation: Moffitt Cancer Center & Research Insitute
Series	BIRS Workshop Lecture Videos (Banff, Alta)
Date Available	2019-12-19
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0387222
URI	http://hdl.handle.net/2429/72860
Affiliation	Non UBC
Peer Review Status	Unreviewed
Scholarly Level	Researcher
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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Ductal Microinvasions: Cell and Matrix Interactions in Normal and Cancerous Tissues Rejniak, Katarzyna

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