Title	Stochastically Organizing the Early Mammalian Embryo
Creator	Holmes, Bill
Publisher	Banff International Research Station for Mathematical Innovation and Discovery
Date Issued	2019-06-19T20:10
Description	A critical first even in mammalian development is construction of the inner cell mass and trophoectoderm surrounding it. Using imaging and computational modeling, we show that by controlling the pace of cell fate specification, the embryo creates a crucial window of time where regulatory noise promotes accurate organization of these structures. Imaging results further indicate different gene products (Oct4 and Cdx2) exhibit significantly different levels of noise variation. Surprisingly, this asymmetry provides a novel means to balance the positive and negative influence of stochasticity. More generally, these results indicate noise has a positive role in spatially organizing the embryo.
Extent	40.0 minutes
Subject	Mathematics; Biology and other natural sciences; Partial differential equations; Mathematical biology
Type	Moving Image
File Format	video/mp4
Language	eng
Notes	Author affiliation: Vanderbilt
Series	BIRS Workshop Lecture Videos (Banff, Alta)
Date Available	2019-12-17
Provider	Vancouver : University of British Columbia Library
Rights	Attribution-NonCommercial-NoDerivatives 4.0 International
DOI	10.14288/1.0387167
URI	http://hdl.handle.net/2429/72806
Affiliation	Non UBC
Peer Review Status	Unreviewed
Scholarly Level	Researcher
Rights URI	http://creativecommons.org/licenses/by-nc-nd/4.0/
Aggregated Source Repository	DSpace

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Stochastically Organizing the Early Mammalian Embryo Holmes, Bill

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